Sjögren’s Syndrome is one of the most common yet misunderstood autoimmune disorders in the world today. It’s often brushed off as a “dry eye and dry mouth” condition, but what many don’t realize is that this chronic, systemic illness can severely affect multiple organs—sometimes leading to irreversible complications. With July 23 marking World Sjögren’s Day, experts are urging for more awareness, earlier diagnosis, and a patient-first approach to treatment.World Sjögren’s Day is observed every year on July 23, to honor Dr. Henrik Sjögren—the Swedish ophthalmologist who first identified the condition in 1933. The day is not just symbolic. It’s a global movement to educate the public, highlight patient voices, and push for research and policy changes.The 2025 theme “Awareness Through Research” puts the spotlight on how patients—when given the space to share their experiences—can drive scientific breakthroughs and better clinical outcomes.What is Sjogren's Disease?Sjögren’s Disease is a chronic autoimmune disorder where the body’s immune system mistakenly attacks its own healthy cells—primarily the moisture-producing glands. Most commonly, this results in dry eyes and dry mouth, but Sjögren’s doesn’t stop there. It can also affect other parts of the body including the joints, lungs, kidneys, nerves, digestive system, and even the skin.The condition is often misdiagnosed or diagnosed late because its symptoms—like fatigue, burning eyes, or trouble swallowing—are frequently dismissed as signs of aging, stress, or dehydration. That delay in diagnosis can be dangerous, since Sjögren’s is also linked to a higher risk of lymphoma, a type of cancer.It affects an estimated 4 million people in the U.S., mostly women over 40, though it can occur at any age. While there is no cure, early detection and a coordinated care approach can significantly improve quality of life and prevent long-term damage.In the U.S. alone, an estimated 4 million people live with Sjögren’s. Yet, for most patients, getting diagnosed takes 3 to 5 years, sometimes longer. Dr. Pawan Gupta, Senior Cataract & Retina Surgeon, explains why, “Symptoms like dry eyes, fatigue or dry mouth are so common, they’re often misattributed to dehydration, stress, screen time or aging. This leads to delayed referrals and misdiagnoses.”That delay is costly, Sjögren’s doesn’t just stay in the eyes and mouth—it can quietly affect lungs, kidneys, nerves, joints and even increase the risk of lymphoma.What are the early signs and symptoms of Sjogren’s Syndrome?While every case is different, the most reported symptoms include:Persistent dry eyes or burning sensationDry mouth and difficulty swallowingChronic fatigueJoint painDental cavities or oral infectionsVaginal drynessBrain fog or memory lapsesThese may seem harmless at first—but when ignored, they point to a deeper autoimmune imbalance that can worsen with time.Why Sjögren’s Isn’t Just a ‘Mild Autoimmune Condition’?Sjogren’s Syndrome is often mistakenly believed to be a mild autoimmune disease because the early symptoms, dry eyes and dry mouth, seem harmless and are easily overlooked. Dr Pawan says, "This disease can be anything but minor. It is a systemic autoimmune disorder that results when the body's immune system attacks the glands that produce moisture, namely the lacrimal ) and salivary glands. This can lead to serious complications, involving multiple organs, over time, it goes from discomfort to widespread complications."Sjogren's progresses to potentially affect the lungs, kidneys, joints, nerves, and gastrointestinal system. "Many patients also suffer from chronic fatigue, debilitating pain in their joints and an increased risk for lymphoma. The complexity of the condition may require a multi-specialty approach that involves a rheumatologist, ophthalmologist and pulmonologist. The perception that Sjogren’s is a benign condition, means that aggressive management is delayed and can potentially deprive patients of optimal quality of life. Time is of the essence for early intervention to stop irreversible damage, especially to the eyes and internal organs. Sjögren’s should be viewed as a serious, chronic and often progressive disease requiring long-term comprehensive care management," adds Dr Pawan.Does Sjögren’s Syndrome Takes Years to Diagnose?Sjögren’s Syndrome can take many years to identify, and Dr Gupta evidently explains, "Since the early symptoms of dry mouth, dry eyes, and mild fatigue could be easily ascribed to more common and easily explained reasons such as dehydration, adverse effects of medications, or just aging. Physicians might not think of the diagnosis of an autoimmune disorder without other obvious pertinent reasons or signs. In addition, these early symptoms might accompany other disorders and clinical conditions, making other relevant areas of differential diagnosis difficult."Initially in their disease, most of the general physicians they visit would not recognize the underlying immune dysfunction and that treating the symptoms may be treating the symptoms only. Another aspect that doesn't make diagnosis easier is the process to obtain a definitive diagnosis. There is not a single definitive test for Sjögren’s. Most patients receive a diagnosis following a battery of lab tests, eye exams, imaging, or biopsies of salivary glands and extensive history, simultaneously and serologically completing the diagnostic picture. As Sjogren progresses slowly, there may not be systemic problems until much later in the disease, delaying diagnosis even longer. "Delaying the diagnosis of Sjogren’s means the patients will suffer for a longer period and are at increased risk from complications due to it being an auto-immune disorder. Increasing awareness about early symptoms of patients and having physicians diagnosing and referring to rheumatologists may assist in achieving timely diagnosis and management of this complex disease," emphasises Dr Gupta.Does Dry Eyes Become a Progressive, Permanent Risk for Sjögren’s Syndrome?Yes, if untreated, dry eyes can become a progressive and potentially permanent problem for those with Sjogren's Syndrome. In Sjogren's Syndrome, the immune system attacks the lacrimal glands and dramatically decreases the production of tears. When that happens, the natural tear film that protects and nourishes your eye can become unstable, leading to certain ocular issues such as irritation, blurred vision, burning, and potentially corneal damage in long-standing situations. As a result of untreated dryness, chronic dryness leads to long-term complications in many cases. Serious complications range from corneal ulcers, corneal infections, and lastly, permanent vision loss. Dr Gupta points out, "Treatment for dry eyes in Sjogren's starts with frequent artificial tear use to keep your eye surface moist. In more progressive cases, punctal plugs may assist in holding your natural tears by blocking the drainage through your tear ducts. It is important to follow up regularly with your eye care specialist. Since Sjogren's is progressive, it is good practice to take proactive and continued care of your eyes to preserve vision as well as prevent irreversible damage."What are the Treatment Options for Sjögren’s today?There is no cure, but a multi-specialty approach helps manage symptoms and slow progression:For dry eyes: Artificial tears, prescription anti-inflammatories, punctal plugsFor dry mouth: Saliva substitutes, sugar-free lozenges, good oral hygiene, regular dental careSystemic symptoms: Hydroxychloroquine, corticosteroids, immunosuppressantsLifestyle adjustments: Hydration, humidifiers, avoiding triggers (like alcohol or caffeine), and pacing energyPatients often need coordination between a rheumatologist, ophthalmologist, dentist, ENT and sometimes neurologist.What makes the 2025 theme ‘Awareness Through Research’ important?This year’s theme recognizes that real progress in Sjögren’s research has come from patients who speak up.Their stories are shaping new clinical trials, earlier screening tools, and even new drug development. Salivary gland imaging, lab biomarkers, and tear analysis are all becoming more advanced thanks to this growing patient-led momentum.If you're experiencing persistent dry eyes, dry mouth, or crushing fatigue, don’t dismiss it—and don’t let others dismiss it either. If symptoms don’t improve or begin to cluster, especially with joint pain or swelling, ask your doctor directly about a referral to a rheumatologist. Early intervention can change the course of this disease.For doctors, it’s time to challenge the common assumptions. Not every case of dry eyes stems from excessive screen time or aging. If your patient presents with multiple vague, systemic complaints—dryness, fatigue, brain fog—consider Sjögren’s syndrome early, rather than as a diagnosis of exclusion.For the public, awareness is everything. Most people with Sjögren’s don’t “look sick", but behind the scenes, they’re managing a complex, exhausting autoimmune condition daily. Sjögren’s may be quiet, but it’s not mild. It deserves sharper clinical attention, more robust support systems, and far greater visibility in the conversation around chronic illness.Dr. Pawan Gupta, Senior Cataract & Retina Surgeon, Eye 7 Hospitals Lajpat Nagar & Vision Eye Clinic New Delhi