Health and Me

Ishita Roy

FDA Approves Cabozantinib For Neuroendocrine Tumors

The United States Food and Drug Administration has recently approved cabozantinib (Cabometyx) for patients with previously treated advanced neuroendocrine tumors. This is an oral tyrosine kinase inhibitor, which is offering a new standard for care of this patient group. This has been announced by the Dana-Farber Cancer Institute. 

The approval came on the bases of the results from the phase 3 CABINET study. The study compared cabozantinib to a placebo in patients with advanced pancreatic neuroendocrine tumors. 

As per the National Cancer Institute, <span>neuroendocrine tumor</span> grows from neuroendocrine cells. These cells receive and send messages through hormones to help the body function. These cells are found in organs throughout the body. The neuroendocrine tumor was called carcinoid tumor 

These tumors grow very slowly and are mostly found in appendix, also known as appendiceal neuroendocrine tumors. When found in lungs, they are also called bronchial tumors. These areas are more common in children and young adults. Whereas for adults, it is mostly found in the digestive tract, called the GI neuroendocrine tumor. What makes it concerning is that it can also spread to other parts of the body but does so more in adults than in children. 

They are rare in children and more common in adults, affecting up to 4 in 100,000 adults. 

The drug which FDA has approved based on the phase 3 CABINER study's results have been published last September in the New England Journal of Medicine. Patients who were treated with cabozantinib survived significantly longer with no worsening of their disease compared with patients who received placebo. This also improved the efficacy as was observed in the interim analysis. The trial was in fact terminated early and unblinded in August 2023. 

<h4>Are There Any Side Effects From The FDA Approved Drugs?</h4>

The reported side effects of cabozantinib were similar to those found in other studies of the drug. They include:

<ul><li>Hypertension</li><li>Fatigue</li><li>Diarrhea</li></ul>

"Patients with neuroendocrine tumors often face a difficult journey," lead author of the CABINET study, Jennifer Chan, M.D., M.P.H., of the Dana-Farber Cancer Institute, said in a statement. "Despite advances in recent years, there has remained a critical need for new and effective therapies for patients whose cancer has grown or spread. Cabozantinib significantly improved outcomes in this patient population and this FDA approval provides new hope."

<h4>How Is Neuroendocrine tumor diagnosed?</h4>

While some people have symptoms, others may do not have any symptoms. These symptoms depends on where in your body the tumor has grown. 

Patients who have appendiceal neuroendocrine tumors may have symptoms of appendicitis, such as pain in abdomen. They could also be later diagnosed with carcinoid tumor in case the doctor removes the appendix and finds a tumor. Patients with carcinoid tumor in other parts of the digestive tract may have symptoms such as:

<ul><li>Pain in the abdomen</li><li>Nausea or vomiting</li><li>Diarrhea</li></ul>

Other ways to detect is by lab tests, imaging, and biopsy. 

Health Conditions A-Z

health

neuroendocrine tumor

health news

us health news

FDA approves new drug

FDA drug approval

Untimely Rainfall Leaves The Country Prone To These Infectious Diseases

This 'Sweet and Sour' Fruit Juice Can Help Ease Sore Throat While Reducing Your Cancer Risk

You Can Reduce Dementia Risk By Walking Only These Number Of Steps

Health News

Healthy Drinks That Improve Your Digestion

World Tobacco Day: Unexpected Ways Smoking Can Affect You

Seasonal Mood Swings? How Weather Affects Mental Health

Is Calorie Counting Healthy? Dos And Don’ts

Heat-Related Illnesses That You Should Know

Menstrual Hygiene Day: Tips On Period Hygiene

​Add These High Protein Vegetarian Meals To Your Diet​

Top 10 Workouts That Burn Most Calorie

Makhana Season – Healthy &amp; Quick Foxnut Recipes

Monsoon Ahead – Tips On Building Rainy Season Immunity

Do You Have Prickly Heat Rash – Symptoms, Causes And Treatment

Healthy No-Cook Recipes You Can Try

How Do You Calorie Count – Numbers And Nutrients

Unexpected Signs Of Dehydration – Safety And Precaution Measures

Leg Exercises You Can Do At Home To Build Strength

Foods That Promote Skin Elasticity

Must-Do Chest Exercises You Can Try At Home

What Are The Symptoms Of JN.1 COVID-19 Strain?

Why Does Sleeping Become Harder As You Age?

High-Fiber Healthy Drinks You Should Try

10 Dumbbell Exercise Variations For Upper-Body Strength

A Parent’s Guide To Pets: Important Points To Consider For Your Child’s Health

Food Anxiety Is Real – How Your Food Intake Affects Your Anxiety

World Osteoporosis Month: Ways To Strengthen Your Bones

Brain Exercises To Keep You Cognitively Sharp

Easy Recipes To Make When You Don’t Wish To Cook

Physical Signs Of High Cortisol

9 Healthy Plant-Based Protein Rich Dishes To Try

What Happens When You Have Low Blood Pressure?

Throw These Toxic Bathroom Items Away To Protect Your Health

This Is What Cricket Superstar Virat Kohli Eats In A Day

Signs You Are Experiencing Sensory Overload

Shoulder Exercises You Should Do For Defined Shoulders

Best Foods To Eat When You Are Fasting

​Ghee For Ayurveda: Why It Should Be A Part Of Your Diet​

Symptoms Of Ovarian Cancer You Should Know

Yoga Poses That Can Build Core Strength

Biotin-Rich Foods You Should Add To Your Diet

Unexpected Physical Signs Of Stress

Simple And Affective Guide To Stop A Panic Attack

The United States Food and Drug Administration has recently approved cabozantinib (Cabometyx) for patients with previously treated advanced neuroendocrine tumors. This is an oral tyrosine kinase inhibitor, which is offering a new standard for care of this patient group. This has been announced by the Dana-Farber Cancer Institute. How Was The Drug Approved?The approval came on the bases of the results from the phase 3 CABINET study. The study compared cabozantinib to a placebo in patients with advanced pancreatic neuroendocrine tumors. As per the National Cancer Institute, neuroendocrine tumor grows from neuroendocrine cells. These cells receive and send messages through hormones to help the body function. These cells are found in organs throughout the body. The neuroendocrine tumor was called carcinoid tumor These tumors grow very slowly and are mostly found in appendix, also known as appendiceal neuroendocrine tumors. When found in lungs, they are also called bronchial tumors. These areas are more common in children and young adults. Whereas for adults, it is mostly found in the digestive tract, called the GI neuroendocrine tumor. What makes it concerning is that it can also spread to other parts of the body but does so more in adults than in children. They are rare in children and more common in adults, affecting up to 4 in 100,000 adults. The drug which FDA has approved based on the phase 3 CABINER study's results have been published last September in the New England Journal of Medicine. Patients who were treated with cabozantinib survived significantly longer with no worsening of their disease compared with patients who received placebo. This also improved the efficacy as was observed in the interim analysis. The trial was in fact terminated early and unblinded in August 2023. Are There Any Side Effects From The FDA Approved Drugs?The reported side effects of cabozantinib were similar to those found in other studies of the drug. They include:HypertensionFatigueDiarrhea"Patients with neuroendocrine tumors often face a difficult journey," lead author of the CABINET study, Jennifer Chan, M.D., M.P.H., of the Dana-Farber Cancer Institute, said in a statement. "Despite advances in recent years, there has remained a critical need for new and effective therapies for patients whose cancer has grown or spread. Cabozantinib significantly improved outcomes in this patient population and this FDA approval provides new hope."How Is Neuroendocrine tumor diagnosed?While some people have symptoms, others may do not have any symptoms. These symptoms depends on where in your body the tumor has grown. Patients who have appendiceal neuroendocrine tumors may have symptoms of appendicitis, such as pain in abdomen. They could also be later diagnosed with carcinoid tumor in case the doctor removes the appendix and finds a tumor. Patients with carcinoid tumor in other parts of the digestive tract may have symptoms such as:Pain in the abdomenNausea or vomitingDiarrheaOther ways to detect is by lab tests, imaging, and biopsy. 

fda approves cabozantinib for neuroendocrine tumors

Tanya Dutt

Type 2 Diabetes And High Blood Pressure Now Affect 1 In 8 Americans, Study Links Combo To Early Death Risk

Type 2 Diabetes And High BP Now Affect 1 In 8 Americans, Study Links Combo To Early Death Risk

Nutrition

Can Eating Too Much Ginger, Cloves, Cinnamon Or Turmeric Interfere With Your Daily Medication?

can eating too much ginger, cloves, cinnamon or turmeric interfere with your daily medication?

Health & Wellness

What Are The Physical Symptoms Of Stress?

what are the physical symptoms of stress?

From Natural Pain Relief To Cancer Prevention: Surprising Health Benefits Of Guava Fruit And Leaves

from natural pain relief to cancer prevention: surprising health benefits of guava fruit and leaves

Colon Cancer Is Rising In Millennials- But This One Symptom Still Feels Too Embarrassing To Talk About

colon cancer is rising in millennials- but this one symptom still feels too embarrassing to talk about

A new long-term study has revealed a troubling health trend in the United States: the number of Americans living with both <span>type 2 diabetes</span> and <span>high blood pressure</span> has doubled over the last two decades, with 1 in 8 adults now affected. Even more concerning is the steep rise in mortality risk associated with this dual diagnosis—suggesting that the combo of these two chronic diseases may be deadlier than previously understood.

Published in the peer-reviewed journal Diabetes Care, the study spans nearly 20 years and highlights how a rapidly increasing population is living with multiple metabolic risk factors—a condition that significantly raises the odds of heart disease, stroke, kidney failure, and early death.

Researchers at Columbia University's Mailman School of Public Health mined health information from close to 49,000 American adults who took part in the National Health and Nutrition Examination Survey from 1999 through 2018. The National Center for Health Statistics conducted the survey, which captures interviews, laboratory tests, and physical exams to measure the health of the country.

According to the study, only 6% of Americans in 1999 suffered from both type 2 diabetes and high blood pressure. By 2018, it had risen to 12%, or about 1 in 8 adults. Those with both conditions were more than twice as likely to die from any cause and three times more likely to die from heart disease than those with neither condition.

"Even having co-existing prediabetes and high blood pressure was linked to up to 19% greater risk of death," said lead researcher Dr. Nour Makarem, assistant professor of epidemiology at Columbia University.

This is important because it indicates that heightened risk begins even before someone officially qualifies by clinical criteria as having diabetes or hypertension.

<h2>Why This Compounds To Health Risks?</h2>

Having either condition on its own—type 2 diabetes or high blood pressure—already raises one's risk for severe complications but when they occur together, their interaction in the cardiovascular system is much more destructive.

Approximately two out of three patients with type 2 diabetes have high blood pressure or are prescribed medication for it. Among individuals with both disease states, about 33% died over a median 9-year follow-up period.

For individuals with only one condition, the mortality rate remained at 20–22%, whereas individuals with neither condition suffered from a mere 6% fatality during the same period of time.

The research identified that in comparison with individuals with:

Hypertension alone, developing both conditions increased the risk for all-cause mortality by 66% as well as cardiovascular death by 54%.

Type 2 diabetes alone, but with both conditions, overall risk of death was 25% higher and greater than two-fold increased cardiovascular mortality.

<h2>Why This Disease Pair Is So Deadly?</h2>

Both type 2 diabetes and high blood pressure are "silent killers." Alone, they tend to produce no discernible symptoms until complications—such as stroke, heart failure, or kidney damage—arise. Combined, however, they provide a deadly combination of cardiovascular stress.

Diabetes disables the body's ability to keep blood sugar in balance. High glucose levels destroy blood vessels and organs by repeated damage.

Hypertension makes the heart work harder to circulate blood, which hardens and weakens the arteries.

When both conditions occur together, this speeds up the deterioration of the arteries, kidneys, and heart, making heart attack, stroke, and end-stage renal disease requiring dialysis or transplantation more likely.

<h2>Early Warning Signs That Are Often Missed</h2>

Another significant takeaway of the research is that the danger of death starts even prior to a full-blown diagnosis. Prediabetic and high-blood-pressure persons—even if they are below diagnostic levels—had a 19% greater risk of mortality.

Although type 2 diabetes can quietly develop without apparent symptoms, there are some early warning signs that should never be overlooked—particularly if you're at risk. The sooner you detect diabetes, the less complicated it is to control and prevent long-term complications. Even slight symptoms deserve a chat with your doctor.

- One of the first and most indicative symptoms of high blood sugar is urinating more often, particularly at night. As blood glucose increases, the kidneys work around the clock to flush out the excess glucose. When they're unable to keep pace, glucose leaks into the urine, causing more frequent trips to the bathroom.

- Too much sugar in the urine not only impacts hydration—but also is a breeding ground for bacteria and yeast. This increases the likelihood of infections in the urinary tract and yeast infections, particularly in women. If you find that you have persistent infections that are difficult to clear, you might want to be tested.

- Another visible clue is the appearance of dark, velvety patches of skin, typically found in body folds like the neck, armpits, or groin. These areas may indicate insulin resistance—a common precursor to diabetes.

- If you’re eating regularly but still feel hungry all the time, your cells may not be properly absorbing glucose. As a result, your body stays in a constant state of seeking energy, driving persistent hunger.

- Ironically, even though you are hungrier, you may actually lose weight unexpectedly. Since there's not enough glucose flowing into cells, your body starts to break down muscle and fat for energy.

- This energy shortage also leads to constant fatigue and weakness. You could be tired, even with a good night's rest. Dehydration caused by frequent urination only adds to that pervasive fatigue.

- Another troubling symptom is blurred vision, which can appear and disappear. High blood glucose can harm the tiny blood vessels in the eyes, leading to more severe conditions—blindness, if not treated.

- Most people experience a tingling or numb feeling in their hands or feet. This is caused by nerve damage from years of high blood sugar levels. Refereed to as diabetic neuropathy, this can also result in long-term chronic pain or loss of sensation.

This result highlights the importance of early screening and proactive prevention measures, particularly for individuals in their 30s and 40s who are unaware they're at risk. The research also reignites debate around various forms of diabetes, many of which have different risks:

Type 1 Diabetes: Autoimmune condition in which the pancreas releases no insulin.

Type 2 Diabetes: A metabolic disorder in which the body fails to utilize insulin. Frequently associated with obesity, a diet lacking in nutritious foods, and physical inactivity.

Prediabetes: A silent diabetes precursor with no warning signs.

Gestational Diabetes: Appears during pregnancy and increases risk of type 2 diabetes in the future.

Of these, type 2 diabetes is the most common and can be directly associated with lifestyle modifications that are often possible.

This highlights the pressing need for public health approaches to prevent and manage these diseases and to halt these negative trends," Dr. Makarem stressed.

At present, approximately two-thirds of adults with diabetes have blood pressure above 130/80 mm Hg or are taking antihypertensive therapy.

Since most symptoms are mild or undetectable, screening is necessary on a regular basis. The American Diabetes Association suggests that all adults over the age of 45 should be screened for diabetes. If you are younger but have risk factors that include obesity, being inactive, having a poor diet, or a family history of diabetes, you need to be tested too.

Screening is typically a straightforward blood test. If normal, the ADA recommends repeat testing at three-year intervals to track changes.

As an ageing population, inactive lifestyles and obesity on the rise, the co-epidemic of diabetes and high blood pressure is set to expand unless there are systemic changes.

heart health

type 2 diabetes

high blood pressure

diabetes and hypertension

heart disease risk

early death risk

diabetes complications

us health statistics

A new long-term study has revealed a troubling health trend in the United States: the number of Americans living with both type 2 diabetes and high blood pressure has doubled over the last two decades, with 1 in 8 adults now affected. Even more concerning is the steep rise in mortality risk associated with this dual diagnosis—suggesting that the combo of these two chronic diseases may be deadlier than previously understood.Published in the peer-reviewed journal Diabetes Care, the study spans nearly 20 years and highlights how a rapidly increasing population is living with multiple metabolic risk factors—a condition that significantly raises the odds of heart disease, stroke, kidney failure, and early death.Researchers at Columbia University's Mailman School of Public Health mined health information from close to 49,000 American adults who took part in the National Health and Nutrition Examination Survey from 1999 through 2018. The National Center for Health Statistics conducted the survey, which captures interviews, laboratory tests, and physical exams to measure the health of the country.According to the study, only 6% of Americans in 1999 suffered from both type 2 diabetes and high blood pressure. By 2018, it had risen to 12%, or about 1 in 8 adults. Those with both conditions were more than twice as likely to die from any cause and three times more likely to die from heart disease than those with neither condition."Even having co-existing prediabetes and high blood pressure was linked to up to 19% greater risk of death," said lead researcher Dr. Nour Makarem, assistant professor of epidemiology at Columbia University.This is important because it indicates that heightened risk begins even before someone officially qualifies by clinical criteria as having diabetes or hypertension.Why This Compounds To Health Risks?Having either condition on its own—type 2 diabetes or high blood pressure—already raises one's risk for severe complications but when they occur together, their interaction in the cardiovascular system is much more destructive.Approximately two out of three patients with type 2 diabetes have high blood pressure or are prescribed medication for it. Among individuals with both disease states, about 33% died over a median 9-year follow-up period.For individuals with only one condition, the mortality rate remained at 20–22%, whereas individuals with neither condition suffered from a mere 6% fatality during the same period of time.The research identified that in comparison with individuals with:Hypertension alone, developing both conditions increased the risk for all-cause mortality by 66% as well as cardiovascular death by 54%.Type 2 diabetes alone, but with both conditions, overall risk of death was 25% higher and greater than two-fold increased cardiovascular mortality.Why This Disease Pair Is So Deadly?Both type 2 diabetes and high blood pressure are "silent killers." Alone, they tend to produce no discernible symptoms until complications—such as stroke, heart failure, or kidney damage—arise. Combined, however, they provide a deadly combination of cardiovascular stress.Diabetes disables the body's ability to keep blood sugar in balance. High glucose levels destroy blood vessels and organs by repeated damage.Hypertension makes the heart work harder to circulate blood, which hardens and weakens the arteries.When both conditions occur together, this speeds up the deterioration of the arteries, kidneys, and heart, making heart attack, stroke, and end-stage renal disease requiring dialysis or transplantation more likely.Early Warning Signs That Are Often MissedAnother significant takeaway of the research is that the danger of death starts even prior to a full-blown diagnosis. Prediabetic and high-blood-pressure persons—even if they are below diagnostic levels—had a 19% greater risk of mortality.Although type 2 diabetes can quietly develop without apparent symptoms, there are some early warning signs that should never be overlooked—particularly if you're at risk. The sooner you detect diabetes, the less complicated it is to control and prevent long-term complications. Even slight symptoms deserve a chat with your doctor.- One of the first and most indicative symptoms of high blood sugar is urinating more often, particularly at night. As blood glucose increases, the kidneys work around the clock to flush out the excess glucose. When they're unable to keep pace, glucose leaks into the urine, causing more frequent trips to the bathroom.- Too much sugar in the urine not only impacts hydration—but also is a breeding ground for bacteria and yeast. This increases the likelihood of infections in the urinary tract and yeast infections, particularly in women. If you find that you have persistent infections that are difficult to clear, you might want to be tested.- Another visible clue is the appearance of dark, velvety patches of skin, typically found in body folds like the neck, armpits, or groin. These areas may indicate insulin resistance—a common precursor to diabetes.- If you’re eating regularly but still feel hungry all the time, your cells may not be properly absorbing glucose. As a result, your body stays in a constant state of seeking energy, driving persistent hunger.- Ironically, even though you are hungrier, you may actually lose weight unexpectedly. Since there's not enough glucose flowing into cells, your body starts to break down muscle and fat for energy.- This energy shortage also leads to constant fatigue and weakness. You could be tired, even with a good night's rest. Dehydration caused by frequent urination only adds to that pervasive fatigue.- Another troubling symptom is blurred vision, which can appear and disappear. High blood glucose can harm the tiny blood vessels in the eyes, leading to more severe conditions—blindness, if not treated.- Most people experience a tingling or numb feeling in their hands or feet. This is caused by nerve damage from years of high blood sugar levels. Refereed to as diabetic neuropathy, this can also result in long-term chronic pain or loss of sensation.This result highlights the importance of early screening and proactive prevention measures, particularly for individuals in their 30s and 40s who are unaware they're at risk. The research also reignites debate around various forms of diabetes, many of which have different risks:Type 1 Diabetes: Autoimmune condition in which the pancreas releases no insulin.Type 2 Diabetes: A metabolic disorder in which the body fails to utilize insulin. Frequently associated with obesity, a diet lacking in nutritious foods, and physical inactivity.Prediabetes: A silent diabetes precursor with no warning signs.Gestational Diabetes: Appears during pregnancy and increases risk of type 2 diabetes in the future.Of these, type 2 diabetes is the most common and can be directly associated with lifestyle modifications that are often possible.This highlights the pressing need for public health approaches to prevent and manage these diseases and to halt these negative trends," Dr. Makarem stressed.At present, approximately two-thirds of adults with diabetes have blood pressure above 130/80 mm Hg or are taking antihypertensive therapy.Since most symptoms are mild or undetectable, screening is necessary on a regular basis. The American Diabetes Association suggests that all adults over the age of 45 should be screened for diabetes. If you are younger but have risk factors that include obesity, being inactive, having a poor diet, or a family history of diabetes, you need to be tested too.Screening is typically a straightforward blood test. If normal, the ADA recommends repeat testing at three-year intervals to track changes.As an ageing population, inactive lifestyles and obesity on the rise, the co-epidemic of diabetes and high blood pressure is set to expand unless there are systemic changes.

type 2 diabetes and high blood pressure now affect 1 in 8 americans, study links combo to early death risk

India Records 3,395 Active COVID-19 Cases, 26 Deaths, Kerala and Maharashtra Among Worst-Hit States

Covid Cases Surge Again In India, But This Time It’s Your Stomach And Throat That Suffer First; New Symptoms To Note

covid cases surge again in india, but this time it’s your stomach and throat that suffer first; new symptoms to note

Which COVID-19 Variants Are Going Around The World In 2025?

which covid-19 variants are going around the world in 2025?

Pregnant Amid The JN.1 Covid Surge? What Expecting Moms Must Know, According to Experts

pregnant amid the jn.1 covid surge? what expecting moms must know, according to experts

Man Dies After Tick Bite ‘Blew Up’ His Brain: What Kind Of Ticks Carry The Deadly Powassan Virus?

man dies after tick bite ‘blew up’ his brain: what kind of ticks carry the deadly powassan virus?

India is seeing a new surge in COVID-19 cases, with active cases reaching over 3,395 as of May 31 — nearly three times the number in a little over two weeks. Kerala, Maharashtra, and Delhi have turned into the biggest hotspots, even though health authorities continue to insist that severity is low. The increase, while not alarming in terms of hospitalizations, has seen India's health authorities keeping a closer watch with the identification of new Omicron subvariants and local clusters of cases.

With a sharp spike in active cases India is back on the global health radar. Though the numbers are still low compared to earlier waves, the rising trend in a number of states, along with the identification of new Omicron subvariants, is worth examining.

India has witnessed an increase in active COVID-19 cases threefold in the last two weeks, from 1,010 on May 19 to 3,395 on May 31, with official government data. The rise is specifically prominent in Kerala, Maharashtra, and Delhi — regions that have typically been early warning signs of wider transmission trends within the country.

Kerala, which currently holds the highest number of active cases at 1,336, has seen a surge from just 430 cases reported on May 26. Maharashtra follows closely with 467 active cases, more than doubling from its 209 count just days ago. Delhi’s trajectory is also concerning, with a leap from 105 to 375 cases in the same period.

Although these figures are still small compared to the peak of the pandemic, the week-on-week surge suggests a possible first wave of transmission that is being watched closely by experts.

As much as there has been an increase in case numbers, the severity of infection is still low, highlight the Indian health officials and experts. Majority of the patients are recovering under home isolation and only a few need hospitalization.

Official sources and the Indian Council of Medical Research (ICMR) indicated that there is "no cause for concern" in terms of public health emergency. ICMR Director General Dr. Rajiv Bahl provided assurances to the public, saying, "As of now, the severity is generally low. There's nothing to worry about. We should be vigilant and always be prepared."

This indicates that even as the rate of transmission could be increasing, the healthcare system is not getting strained, and the virus remains following a clinically milder pattern than in earlier waves.

India's new COVID-19 scenario is extremely regionalized, with southern and western states witnessing initial hints of flare-ups prior to infections starting to rise in northern India.

Here's a closer examination of major states:

<strong>Kerala</strong>: From 430 cases on May 26 to 1,336 on May 31. Six fatalities have been reported.

<strong>Maharashtra</strong>: Cases went from 209 to 467; seven deaths have been reported.

<strong>Delhi</strong>: Triplication of cases, from 105 to 375, with three deaths.

<strong>Karnataka</strong>: From 47 to 234 active cases in under a week.

Tamil Nadu, Gujarat, Uttar Pradesh, West Bengal, Rajasthan, Madhya Pradesh, and Punjab have all experienced moderate increases.

These figures do not only reflect an increase in transmission but a geographical spread that crosses urban and semi-urban hubs, increasing the stakes for surveillance and containment.

Four COVID deaths in India in the past 24 hours — one in each of Delhi, Kerala, Karnataka, and Uttar Pradesh. Although deaths are still in single digits, the number of deaths in this new spike includes:

<ul><li>Kerala (6 deaths since May 26)</li><li>Maharashtra (7 deaths)</li><li>Karnataka and Delhi (3 deaths each)</li><li>Other states like Tamil Nadu, Gujarat, Rajasthan, Madhya Pradesh, and Punjab (1 death each)</li></ul>

With the present low rates of hospitalization and minimal clinical severity, these deaths are being assessed in the context of co-morbidities and age-related susceptibility.

<h2>Is Multi-Variant Spread Behind the Covid Surge In India?</h2>

Epidemiologists are particularly interested in understanding whether new variants may be fueling this latest uptick. According to the Indian SARS-CoV-2 Genomics Consortium (INSACOG), two new Omicron subvariants have been detected in India:

<strong>NB.1.8.1: </strong>Detected in Tamil Nadu in April

<strong>LF.7:</strong> Four cases detected in Gujarat in May

Globally, these variants have contributed to a rise in infections in Southeast Asian countries like Singapore, Hong Kong, and parts of China.

Still, the World Health Organization (WHO) now categorizes both NB.1.8.1 and LF.7 as "variants under monitoring" rather than "variants of concern" or "variants of interest." The WHO's current position is that:

"Based on the evidence available, the added public health risk from NB.1.8.1 is assessed as low at a global level."

The most common circulating strain in India is JN.1, with 53% of the sequenced cases, followed by BA.2 with 26%, while the rest of the 20% consists of other Omicron sublineages.

<h2>Surveillance and Public Health Strategy</h2>

India's response to the ongoing surge is being organized through the Integrated Disease Surveillance Programme (IDSP). The government is focusing on genomic sequencing, local containment strategies, and respiratory hygiene awareness.

Public health messaging remains on high alert but against panic. No restrictions on travel, lockdowns, or new public orders have been implemented thus far.

Dr. Bahl once again reinforced, "People do not need to take any immediate action. They should follow normal precautions. So, there is nothing special to do right now."

That means maintaining current best practices like handwashing, mask-wearing in close indoor environments, and self-isolation when symptomatic.

<h2>Should the World Be Concerned Now?</h2>

For the global community, India's recent development is a reminder of the unpredictable nature of the pandemic. Although the world has largely left behind COVID-19 as an emergency, localized outbreaks in densely populated areas like India can ripple outward — particularly if emerging variants start to demonstrate greater transmissibility or immune escape.

The positive news still is that vaccines continue to provide strong protection against severe illness, and India's national immunization program has maintained high coverage in adult groups. However, ongoing genomic surveillance and real-time data transparency will remain crucial to avert larger outbreaks.

India's COVID-19 surge, while of limited magnitude and clinical severity, is a multifaceted convergence of regional patterns of transmission, emerging variant sequences, and preparedness in public health. With cases being largely mild and mortality rates low, the nation's health care system is still in hand but not resting on its laurels.

In the meantime, there is no cause for global alarm. Nevertheless, India's experience should prompt health systems everywhere to remain on high alert, keep genomic surveillance going, and inform the public in a transparent manner. The virus is evolving, but so is our combined ability to deal with it.

covid-19 india update

kerala covid surge

maharashtra covid cases

delhi covid count

india active covid-19

new covid variant india

covid-19 deaths

India is seeing a new surge in COVID-19 cases, with active cases reaching over 3,395 as of May 31 — nearly three times the number in a little over two weeks. Kerala, Maharashtra, and Delhi have turned into the biggest hotspots, even though health authorities continue to insist that severity is low. The increase, while not alarming in terms of hospitalizations, has seen India's health authorities keeping a closer watch with the identification of new Omicron subvariants and local clusters of cases.With a sharp spike in active cases India is back on the global health radar. Though the numbers are still low compared to earlier waves, the rising trend in a number of states, along with the identification of new Omicron subvariants, is worth examining.India has witnessed an increase in active COVID-19 cases threefold in the last two weeks, from 1,010 on May 19 to 3,395 on May 31, with official government data. The rise is specifically prominent in Kerala, Maharashtra, and Delhi — regions that have typically been early warning signs of wider transmission trends within the country.Kerala, which currently holds the highest number of active cases at 1,336, has seen a surge from just 430 cases reported on May 26. Maharashtra follows closely with 467 active cases, more than doubling from its 209 count just days ago. Delhi’s trajectory is also concerning, with a leap from 105 to 375 cases in the same period.Although these figures are still small compared to the peak of the pandemic, the week-on-week surge suggests a possible first wave of transmission that is being watched closely by experts.The Current Clinical ScenarioAs much as there has been an increase in case numbers, the severity of infection is still low, highlight the Indian health officials and experts. Majority of the patients are recovering under home isolation and only a few need hospitalization.Official sources and the Indian Council of Medical Research (ICMR) indicated that there is "no cause for concern" in terms of public health emergency. ICMR Director General Dr. Rajiv Bahl provided assurances to the public, saying, "As of now, the severity is generally low. There's nothing to worry about. We should be vigilant and always be prepared."This indicates that even as the rate of transmission could be increasing, the healthcare system is not getting strained, and the virus remains following a clinically milder pattern than in earlier waves.Where Cases Are Rising?India's new COVID-19 scenario is extremely regionalized, with southern and western states witnessing initial hints of flare-ups prior to infections starting to rise in northern India.Here's a closer examination of major states:Kerala: From 430 cases on May 26 to 1,336 on May 31. Six fatalities have been reported.Maharashtra: Cases went from 209 to 467; seven deaths have been reported.Delhi: Triplication of cases, from 105 to 375, with three deaths.Karnataka: From 47 to 234 active cases in under a week.Tamil Nadu, Gujarat, Uttar Pradesh, West Bengal, Rajasthan, Madhya Pradesh, and Punjab have all experienced moderate increases.These figures do not only reflect an increase in transmission but a geographical spread that crosses urban and semi-urban hubs, increasing the stakes for surveillance and containment.Four COVID deaths in India in the past 24 hours — one in each of Delhi, Kerala, Karnataka, and Uttar Pradesh. Although deaths are still in single digits, the number of deaths in this new spike includes:Kerala (6 deaths since May 26)Maharashtra (7 deaths)Karnataka and Delhi (3 deaths each)Other states like Tamil Nadu, Gujarat, Rajasthan, Madhya Pradesh, and Punjab (1 death each)With the present low rates of hospitalization and minimal clinical severity, these deaths are being assessed in the context of co-morbidities and age-related susceptibility.Is Multi-Variant Spread Behind the Covid Surge In India?Epidemiologists are particularly interested in understanding whether new variants may be fueling this latest uptick. According to the Indian SARS-CoV-2 Genomics Consortium (INSACOG), two new Omicron subvariants have been detected in India:NB.1.8.1: Detected in Tamil Nadu in AprilLF.7: Four cases detected in Gujarat in MayGlobally, these variants have contributed to a rise in infections in Southeast Asian countries like Singapore, Hong Kong, and parts of China.Still, the World Health Organization (WHO) now categorizes both NB.1.8.1 and LF.7 as "variants under monitoring" rather than "variants of concern" or "variants of interest." The WHO's current position is that:"Based on the evidence available, the added public health risk from NB.1.8.1 is assessed as low at a global level."The most common circulating strain in India is JN.1, with 53% of the sequenced cases, followed by BA.2 with 26%, while the rest of the 20% consists of other Omicron sublineages.Surveillance and Public Health StrategyIndia's response to the ongoing surge is being organized through the Integrated Disease Surveillance Programme (IDSP). The government is focusing on genomic sequencing, local containment strategies, and respiratory hygiene awareness.Public health messaging remains on high alert but against panic. No restrictions on travel, lockdowns, or new public orders have been implemented thus far.Dr. Bahl once again reinforced, "People do not need to take any immediate action. They should follow normal precautions. So, there is nothing special to do right now."That means maintaining current best practices like handwashing, mask-wearing in close indoor environments, and self-isolation when symptomatic.Should the World Be Concerned Now?For the global community, India's recent development is a reminder of the unpredictable nature of the pandemic. Although the world has largely left behind COVID-19 as an emergency, localized outbreaks in densely populated areas like India can ripple outward — particularly if emerging variants start to demonstrate greater transmissibility or immune escape.The positive news still is that vaccines continue to provide strong protection against severe illness, and India's national immunization program has maintained high coverage in adult groups. However, ongoing genomic surveillance and real-time data transparency will remain crucial to avert larger outbreaks.India's COVID-19 surge, while of limited magnitude and clinical severity, is a multifaceted convergence of regional patterns of transmission, emerging variant sequences, and preparedness in public health. With cases being largely mild and mortality rates low, the nation's health care system is still in hand but not resting on its laurels.In the meantime, there is no cause for global alarm. Nevertheless, India's experience should prompt health systems everywhere to remain on high alert, keep genomic surveillance going, and inform the public in a transparent manner. The virus is evolving, but so is our combined ability to deal with it.

India Records 3,395 Active COVID-19 Cases, 26 Deaths, Kerala And Maharashtra Among Worst-Hit States

india records 3,395 active covid-19 cases, 26 deaths, kerala and maharashtra among worst-hit states

Cook County Health Grapples With Lost Grants Amid Federal Pullback

Trump Government Ends Program For HIV Vaccine: What Is Means For Healthcare

trump government ends program for hiv vaccine: what is means for healthcare

World No Tobacco Day 2025: How “Safe” Vaping Is Hooking A New Generation On Nicotine?

world no tobacco day 2025: how “safe” vaping is hooking a new generation on nicotine?

The ripple effects of President Donald Trump’s second-term policies continue to unsettle public health agencies nationwide. While the country is still grappling with the aftermath of the COVID-19 pandemic, health officials say recent federal funding cuts are threatening the very infrastructure designed to protect Americans from future crises.

What began as reductions at the federal level has extended to state and local health departments. Roughly $12 billion in federal health funding has been earmarked for elimination, although some of these cuts are on temporary hold due to legal challenges. Local officials warn that even the threat of funding withdrawals is enough to destabilize long-term public health efforts.

<h4>Chicago’s <span rel="noindex">Cook County Health</span> Feels the Impact</h4>

One of the largest public health systems in the U.S., Cook County Health in Chicago, is already feeling the strain. Dr. Erik Mikaitis, CEO of the system, told the US News that two major grants totaling $31 million were abruptly pulled in March. Although the grants were scheduled to end in a few months, the early termination forced the system to speed up its transition plans.

“We were already in a planning stage,” said Mikaitis, “but we just had to accelerate that a little bit.” He noted that while they expect to retain all employees funded through the grants, outreach efforts have taken a hit. The programs, largely aimed at infectious disease prevention and health literacy, are now scaled back.

<h4>Shrinking Resources, Growing Needs</h4>

The ripple effects of President Donald Trump’s second-term policies continue to unsettle public health agencies nationwide. While the country is still grappling with the aftermath of the COVID-19 pandemic, health officials say recent federal funding cuts are threatening the very infrastructure designed to protect Americans from future crises.What began as reductions at the federal level has extended to state and local health departments. Roughly $12 billion in federal health funding has been earmarked for elimination, although some of these cuts are on temporary hold due to legal challenges. Local officials warn that even the threat of funding withdrawals is enough to destabilize long-term public health efforts.Chicago’s Cook County Health Feels the ImpactOne of the largest public health systems in the U.S., Cook County Health in Chicago, is already feeling the strain. Dr. Erik Mikaitis, CEO of the system, told the US News that two major grants totaling $31 million were abruptly pulled in March. Although the grants were scheduled to end in a few months, the early termination forced the system to speed up its transition plans.“We were already in a planning stage,” said Mikaitis, “but we just had to accelerate that a little bit.” He noted that while they expect to retain all employees funded through the grants, outreach efforts have taken a hit. The programs, largely aimed at infectious disease prevention and health literacy, are now scaled back.Shrinking Resources, Growing NeedsMikaitis stressed that federal support underpins a broad range of public health functions—from vaccinations and infectious disease control to food and water safety. The withdrawal of funding creates downstream effects across the health system.“Without public health being robust and able to intervene, we run the risk of having a sicker population,” he said. Smaller clinical sites, already stretched thin, may face closures under the added burden. “And when you reflect that against federal discussions on Medicaid cuts, that creates almost a double impact.”Bracing for Deeper CutsFaced with uncertainty, Cook County Health is preparing for worst-case scenarios. “We’ve taken the tack of really looking at efficiencies—how do we gain revenues before we even look at trying to cut anything,” said Mikaitis. Still, there is concern that deeper cuts, particularly in Medicaid reimbursements, could force reductions in services.Grants currently fund about a third of the Cook County Department of Public Health’s budget. As those funds disappear, essential functions such as infectious disease surveillance may be at risk.Long-Term Prevention at RiskMikaitis pointed to another looming threat: the potential collapse of preventive care and chronic disease management. Cook County is exploring internal synergies—such as integrating the health plan with public health operations—to cushion the blow.But he warned that if Medicaid cuts proceed and more people lose coverage, fewer will seek preventive care. “Are we going to be focusing on controlling high blood pressure,” he asked, “or treating strokes and heart attacks?”For many health officials like Mikaitis, the choice between prevention and crisis response is no choice at all—it’s a compromise no community can afford to make.