Health and Me

Ishita Roy

10 Children Conceived From Same Sperm Diagnosed With Cancer, Investigation Reveals Donor Has Rare Cancer Genes

Ever considered sperm donation or to conceive through this process? If yes, then this news could concern you. While it is true that sperm health and the person who is donating matters, however, sometimes it can go unchecked. The consequence could be life threatening. In another news, a man whose sperm was used to conceive at least 67 children is found to be carrying a rare <span><a href="https://www.healthandme.com/health/cancer">cancer</a></span> causing mutation. Of the children, 10 of them were diagnosed with cancer. This has raised concerns about the lack of internationally agreed limits on the use of donor sperm.

The Guardian reports that two of the children's families reach out to their respective fertility clinics after their kids were diagnosed with cancer. This is when the sperm was linked to a rare genetic mutation. This case was also presented by Dr Edwige Kasper, a French biologist at the European Society of Human Genetics conference in Milan.

The European Sperm Bank confirmed that the rare variant which Kasper's lab concluded was likely to be Li-Fraumeni syndrome. This was also found in the supplied sperm. The syndrome is an inherited predisposition to cancer, and it has been found in more than two children.

<h4>What Is Li-Fraumeni Syndrome (LFS)?</h4>

It is a cancer predisposition syndrome associated with high risks for a broad spectrum of cancers including early-onset cancers. Five cancers types account for the majority of the LFS tumors: adrenocortical carcinomas, breast cancer, central nervous system tumors, ostesarcomas, and soft-tissue sarcomas. Other cancers associated with LFS are leukemia, colorectal cancer, stomach cancer, lung cancer, melanoma, pediatric head and neck cancers, pancreatic cancer, and prostate cancer.

This was named after two American physicians, Frederick Pel Li and Joseph F Fraumeni Jr., who first recognized this syndrome after reviewing the medical records and death certificates of childhood rhabdomyosarcoma patients.

This mutation is caused by germline mutations in the TP53 tumor suppressor gene, also mentioned in Germline TP53 mutations and Li-Fraumeni syndrome study. This encodes a transcription factor (p53) that normally regulates cell cycle and prevents genomic mutations. The variants can be inherited, or can arise from mutations early in embryogenesis, or in one of the parent's germ cells.

<h4>The Impact Of <span rel="noindex">Rare Cancer Gene</span></h4>

A spokesperson of the company, Juli Paulli Budtz, told The Guardian that the company is “deeply affected by this case.”

Budtz also said that “it is simply not possible to detect disease-causing mutations in a person’s gene pool if you don’t know what you’re looking for,” indicating that prior testing may or may not detect this rare genetic mutation in the sperm donor.

Another detail revealed in The Guardian noted that the time of donation was 2008, when cancer was not linked to the genetic mutation. Thus despite any test, it wouldn’t have been possible to know whether the sperm could have been a cancer career. The Guardian also reported that the outlet also said that the donor is in good health.

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10 kids have cancer from same sperm donor

father with cancer gene donated sperm to 67 family

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Ever considered sperm donation or to conceive through this process? If yes, then this news could concern you. While it is true that sperm health and the person who is donating matters, however, sometimes it can go unchecked. The consequence could be life threatening. In another news, a man whose sperm was used to conceive at least 67 children is found to be carrying a rare cancer causing mutation. Of the children, 10 of them were diagnosed with cancer. This has raised concerns about the lack of internationally agreed limits on the use of donor sperm.How Was This Discovered?The Guardian reports that two of the children's families reach out to their respective fertility clinics after their kids were diagnosed with cancer. This is when the sperm was linked to a rare genetic mutation. This case was also presented by Dr Edwige Kasper, a French biologist at the European Society of Human Genetics conference in Milan.The European Sperm Bank confirmed that the rare variant which Kasper's lab concluded was likely to be Li-Fraumeni syndrome. This was also found in the supplied sperm. The syndrome is an inherited predisposition to cancer, and it has been found in more than two children.What Is Li-Fraumeni Syndrome (LFS)?It is a cancer predisposition syndrome associated with high risks for a broad spectrum of cancers including early-onset cancers. Five cancers types account for the majority of the LFS tumors: adrenocortical carcinomas, breast cancer, central nervous system tumors, ostesarcomas, and soft-tissue sarcomas. Other cancers associated with LFS are leukemia, colorectal cancer, stomach cancer, lung cancer, melanoma, pediatric head and neck cancers, pancreatic cancer, and prostate cancer.This was named after two American physicians, Frederick Pel Li and Joseph F Fraumeni Jr., who first recognized this syndrome after reviewing the medical records and death certificates of childhood rhabdomyosarcoma patients.This mutation is caused by germline mutations in the TP53 tumor suppressor gene, also mentioned in Germline TP53 mutations and Li-Fraumeni syndrome study. This encodes a transcription factor (p53) that normally regulates cell cycle and prevents genomic mutations. The variants can be inherited, or can arise from mutations early in embryogenesis, or in one of the parent's germ cells.The Impact Of Rare Cancer GeneA spokesperson of the company, Juli Paulli Budtz, told The Guardian that the company is “deeply affected by this case.”Budtz also said that “it is simply not possible to detect disease-causing mutations in a person’s gene pool if you don’t know what you’re looking for,” indicating that prior testing may or may not detect this rare genetic mutation in the sperm donor.Another detail revealed in The Guardian noted that the time of donation was 2008, when cancer was not linked to the genetic mutation. Thus despite any test, it wouldn’t have been possible to know whether the sperm could have been a cancer career. The Guardian also reported that the outlet also said that the donor is in good health.

10 children conceived from same sperm diagnosed with cancer, investigation reveals donor has rare cancer genes

Aarushi Bhadury

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French Scientist Who Invented Abortion Pills Dies At 98

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We have all had days when things are difficult to remember, you may forget something you did yesterday, or misplaced an important object etc. While these may be normal occurrences that do not have a big reason behind it, imagine this on a much larger scale. Knowing you will forget things, memories and in the end, find yourself facing the difficult diagnosis of cognitive decline. 

<span>Alzheimer's</span> disease, which is a neurodegenerative disease that affects a person's ability to think and depletes their cognitive functions. As you may be aware, Alzheimer's does not have a cure. However, there are medications available that can help reduce the symptoms of it. Researchers have looked into many different aspects of <span>dementia</span>, foods that affect the brain, activities as well as other important factors, to improve the knowledge we have of the disease and its treatment. Some have found great results that could help people identify the disease earlier, helping them get treatment and options to maintain their quality of life. 

New research suggests that the first hints of Alzheimer's disease might show up many years before someone even realizes they're losing their memory. This big discovery could completely change how we fight this disease, which is now the UK's top killer. 

Researchers are saying that problems with spatial awareness could be the earliest signs of Alzheimer's. This means things like having trouble using a GPS, or standing too close to people without realizing it. These signs might appear up to 20 years before more common symptoms like memory loss and confusion. This Seattle based study, looked at the brains of 84 Alzheimer's patients after they died. They found surprising proof that brain cells were dying very early, even before any damage could be seen on brain scans. 

Using advanced computer programs, scientists tracked harmful brain proteins called tau and amyloid, which are strongly linked to Alzheimer's. They found that even small amounts of these proteins damaged important brain cells called inhibitory neurons. Experts explain that finding these first damaged neurons is "crucial for developing treatments to protect them and prevent further cognitive decline." 

These sensitive brain cells seem to be attacked first in what's being called the 'stealth phase' of Alzheimer's. This early damage could start a slow breakdown of thinking abilities that eventually spreads to the parts of the brain responsible for language and memory. The sooner we find the disease, the better our chances are of slowing it down or even stopping it. 

<h2>Growing Problem and What We Can Do </h2>

According to Alzheimer’s Disease International, every 3 seconds, someone in the world develops dementia. In 2020, over 55 million people worldwide were living with dementia. This number is expected to almost double every 20 years, reaching 78 million by 2030 and a staggering 139 million by 2050. 

A large part of this increase will be in developing countries. Already, 60% of people with dementia live in lower and middle-income countries, and this figure is projected to rise to 71% by 2050. The fastest growth in older populations is happening in countries like China, India, and their neighboring regions in South Asia and the Western Pacific. 

Reports like the <span>World Alzheimer Report</span> 2015 (and its updates in 2017 and the WHO's Global Status Report in 2020) provide vital information on how common dementia is, how many new cases appear, and its costs. These reports and studies offer important recommendations for a global approach to dementia. They also look at evidence of recent trends in dementia over time and analyze its wider impact on society.

“Stealth Stage” Of Alzheimer's

world alzheimer report

Alzheimer's

Alzheimer's disease and symptoms

Alzheimer's early symptoms

Alzheimer's treatment

dementia

mental health

We have all had days when things are difficult to remember, you may forget something you did yesterday, or misplaced an important object etc. While these may be normal occurrences that do not have a big reason behind it, imagine this on a much larger scale. Knowing you will forget things, memories and in the end, find yourself facing the difficult diagnosis of cognitive decline. Alzheimer's disease, which is a neurodegenerative disease that affects a person's ability to think and depletes their cognitive functions. As you may be aware, Alzheimer's does not have a cure. However, there are medications available that can help reduce the symptoms of it. Researchers have looked into many different aspects of dementia, foods that affect the brain, activities as well as other important factors, to improve the knowledge we have of the disease and its treatment. Some have found great results that could help people identify the disease earlier, helping them get treatment and options to maintain their quality of life. New research suggests that the first hints of Alzheimer's disease might show up many years before someone even realizes they're losing their memory. This big discovery could completely change how we fight this disease, which is now the UK's top killer. Changes in How You Sense Space Researchers are saying that problems with spatial awareness could be the earliest signs of Alzheimer's. This means things like having trouble using a GPS, or standing too close to people without realizing it. These signs might appear up to 20 years before more common symptoms like memory loss and confusion. This Seattle based study, looked at the brains of 84 Alzheimer's patients after they died. They found surprising proof that brain cells were dying very early, even before any damage could be seen on brain scans. Damage Inside the Brain Using advanced computer programs, scientists tracked harmful brain proteins called tau and amyloid, which are strongly linked to Alzheimer's. They found that even small amounts of these proteins damaged important brain cells called inhibitory neurons. Experts explain that finding these first damaged neurons is "crucial for developing treatments to protect them and prevent further cognitive decline." These sensitive brain cells seem to be attacked first in what's being called the 'stealth phase' of Alzheimer's. This early damage could start a slow breakdown of thinking abilities that eventually spreads to the parts of the brain responsible for language and memory. The sooner we find the disease, the better our chances are of slowing it down or even stopping it. Growing Problem and What We Can Do According to Alzheimer’s Disease International, every 3 seconds, someone in the world develops dementia. In 2020, over 55 million people worldwide were living with dementia. This number is expected to almost double every 20 years, reaching 78 million by 2030 and a staggering 139 million by 2050. A large part of this increase will be in developing countries. Already, 60% of people with dementia live in lower and middle-income countries, and this figure is projected to rise to 71% by 2050. The fastest growth in older populations is happening in countries like China, India, and their neighboring regions in South Asia and the Western Pacific. Reports like the World Alzheimer Report 2015 (and its updates in 2017 and the WHO's Global Status Report in 2020) provide vital information on how common dementia is, how many new cases appear, and its costs. These reports and studies offer important recommendations for a global approach to dementia. They also look at evidence of recent trends in dementia over time and analyze its wider impact on society.

“stealth stage” of alzheimer's could show signs 20 years before the disease itself

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Drinking Even In Moderation Can Increase Your Cancer Risk In This Organ, Finds Study

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<span>Cancer</span> research has come a long way, although dreams of curing cancer as a whole persist. Researchers have found ways to get the disease under control, as well as how to help people become cancer free. The treatment options available for cancer patients are radiation therapy, immunotherapy, chemotherapy, as well as surgeries to cut out or treat targeted areas. However, a groundbreaking study has helped researchers develop a new cancer treatment, that has increased the rate of survival by 40%.

Researchers from Peking University Cancer Hospital &amp; Institute in China, whose findings were published in The Lancet medical journal, stated that this method "could represent a paradigm shift" in care. These exciting results were shared at the American Society of Clinical Oncology's (ASCO) annual conference in Chicago. 

This study is the first-ever randomized controlled trial to investigate CAR-T therapy for solid tumors. Randomized controlled trials are considered the gold standard for proving whether a treatment is effective. 

Now, a significant study presented at the world's largest cancer conference has revealed that CAR-T therapy could also fight solid tumors, which make up about 90% of all adult human cancers. The research, involving over 100 patients with advanced stomach or gastro-oesophageal junction (GEJ) cancer, showed that those treated with CAR-T therapy lived 40% longer on average than patients who received standard care.

CAR-T therapy is a form of immunotherapy where the treatment cells are made by the patient’s own T-cells, which are white blood cells that protect our bodies from infections. These cells are used to fight cancer, according to the National Cancer Institute. Experts call it the “living drug”, as the T-cells are collected from the patients blood, and modified to produce a special protein called chimeric antigen receptors, or CARs. These cells then latch onto the antigens present in the cancer cells. They also enhance the ability of T-cells to kill cancer.

Specifically, patients who got CAR-T cell therapy survived for an average of 7.9 months, compared to 5.5 months with standard care. They also had 3.3 months without their cancer getting worse, compared to 1.8 months for those on standard care. 

<h2>What Does This Mean For Future Cancer Treatments? </h2>

Experts are hailing this as a "groundbreaking milestone" for using CAR-T therapies to treat solid tumors. Some found the results "exciting," calling it a crucial moment that should motivate the cancer research community to keep pushing forward. 

A director of research and partnerships at a prominent cancer research organization found it "encouraging" to see early signs that CAR-T cell therapy could help patients with solid tumors. They noted that while more extensive trials are needed before it can be widely used, it could mark an important step ahead for patients who have had limited treatment options so far. 

Researchers highlighted that the treatment only extended survival by about two months. They also emphasized the importance of finding ways to lower the cost of CAR-T therapy to make it widely accessible. Despite this, they expressed encouragement that this represents another potential treatment option for gastric cancer patients, whose prognosis is generally very poor, hoping it could offer "meaningful longevity." 

leap for solid tumorsnow

New Cancer Therapy

Cancer Therapy Increases Survival Rate

cancer survival rates

Cancer

treatment options for cancer

Cancer research has come a long way, although dreams of curing cancer as a whole persist. Researchers have found ways to get the disease under control, as well as how to help people become cancer free. The treatment options available for cancer patients are radiation therapy, immunotherapy, chemotherapy, as well as surgeries to cut out or treat targeted areas. However, a groundbreaking study has helped researchers develop a new cancer treatment, that has increased the rate of survival by 40%.Researchers from Peking University Cancer Hospital & Institute in China, whose findings were published in The Lancet medical journal, stated that this method "could represent a paradigm shift" in care. These exciting results were shared at the American Society of Clinical Oncology's (ASCO) annual conference in Chicago. This study is the first-ever randomized controlled trial to investigate CAR-T therapy for solid tumors. Randomized controlled trials are considered the gold standard for proving whether a treatment is effective. Major Leap for Solid TumorsNow, a significant study presented at the world's largest cancer conference has revealed that CAR-T therapy could also fight solid tumors, which make up about 90% of all adult human cancers. The research, involving over 100 patients with advanced stomach or gastro-oesophageal junction (GEJ) cancer, showed that those treated with CAR-T therapy lived 40% longer on average than patients who received standard care.CAR-T therapy is a form of immunotherapy where the treatment cells are made by the patient’s own T-cells, which are white blood cells that protect our bodies from infections. These cells are used to fight cancer, according to the National Cancer Institute. Experts call it the “living drug”, as the T-cells are collected from the patients blood, and modified to produce a special protein called chimeric antigen receptors, or CARs. These cells then latch onto the antigens present in the cancer cells. They also enhance the ability of T-cells to kill cancer.Specifically, patients who got CAR-T cell therapy survived for an average of 7.9 months, compared to 5.5 months with standard care. They also had 3.3 months without their cancer getting worse, compared to 1.8 months for those on standard care. What Does This Mean For Future Cancer Treatments? Experts are hailing this as a "groundbreaking milestone" for using CAR-T therapies to treat solid tumors. Some found the results "exciting," calling it a crucial moment that should motivate the cancer research community to keep pushing forward. A director of research and partnerships at a prominent cancer research organization found it "encouraging" to see early signs that CAR-T cell therapy could help patients with solid tumors. They noted that while more extensive trials are needed before it can be widely used, it could mark an important step ahead for patients who have had limited treatment options so far. Researchers highlighted that the treatment only extended survival by about two months. They also emphasized the importance of finding ways to lower the cost of CAR-T therapy to make it widely accessible. Despite this, they expressed encouragement that this represents another potential treatment option for gastric cancer patients, whose prognosis is generally very poor, hoping it could offer "meaningful longevity." 

new cancer therapy increases survival rate by 40%: study

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From time and again doctors have said that no amount of <span>alcohol</span> is good for you. Alcohol, in fact, is a carcinogen. As per the National Human Genome Research Institute, a carcinogen is a substance, organism or agent capable of causing <span>cancer</span>. The International Agency for Research on Cancer (IARC) also classifies alcohol as Group 1 carcinogen, which means, there is enough evidence to conclude that it causes cancers in human. The risk of cancer increases with the amount of alcohol consume, and the risk stats from the first drink. 

As per a new study, it is also linked to <span>pancreatic cancer</span>. While for the longest, the scientific community had "limited" or "inconclusive" connection on it. However, a large study by the World Health Organization's (WHO) IARC looked at data from around 2 million people across 30 studies in four continents. This was done for over 16 years. 

The study found a slight rise in pancreatic cancer risk linked to alcohol consumption, regardless of gender or smoking status. The increase was more pronounced in women consuming 15 grams or more of alcohol daily, and in men who drank 30 grams or more per day.

The study has been published in PLOS Medicine, and it found a modest yet consistent link between alcohol consumption and pancreatic cancer risk. 

The study found that for every 10 grams of alcohol that is consumed by a person on a daily basis, which amounts to a small glass of wine, the pancreatic cancer risk increases by 3 percent. 

Among women who consumed between 15 and 30 grams of alcohol per day, the risk of developing pancreatic cancer increased by 12 percent compared to those with only light intake (0.1–5 grams/day). In men, the danger climbed more steeply—those drinking 30 to 60 grams daily faced a 15 percent higher risk, while men consuming over 60 grams saw their risk surge by a striking 36 percent.

Put simply, if your daily wind-down routine involves more than the occasional drink, it may be worth thinking twice about what that glass is really costing your health.

<h4>How Does Alcohol Pave Way For Pancreatic Cancer?</h4>

Triggers Inflammation: Long-term alcohol use can irritate and inflame the pancreas, a condition known as pancreatitis. Over time, this chronic inflammation becomes a known risk factor for pancreatic cancer.

Damages Genetic Material: When alcohol breaks down in the body, it turns into acetaldehyde—a toxic compound that’s notoriously harsh on DNA. It can lead to mutations and interfere with your body’s natural ability to repair damaged cells.

Disrupts Glucose Balance: Alcohol interferes with glucose metabolism and insulin function. Since the pancreas plays a central role in both, this disruption puts it under considerable stress and may increase the likelihood of tumour development over time.

<strong>Drives Oxidative Stress: </strong>Drinking introduces oxidative stress—an unhealthy imbalance between damaging free radicals and protective antioxidants. This imbalance harms cell structures and creates an environment in which cancer can thrive.

Lowers Immune Defences: Consistent alcohol consumption weakens the immune system, making it harder for the body to detect and eliminate abnormal or potentially cancerous cells before they multiply.

That said, the study isn’t without limitations. It measured alcohol intake only once during the study period and had limited data from Asian populations. It also didn’t explore lifetime drinking patterns or compare the impacts of occasional binge drinking with regular consumption.

While pancreatic cancer ranks twelfth in global cancer incidence, it is far deadlier than its ranking suggests—contributing to roughly 5 percent of all cancer-related deaths worldwide.

alcohol and cancer

alcohol

pancreatic cancer

From time and again doctors have said that no amount of alcohol is good for you. Alcohol, in fact, is a carcinogen. As per the National Human Genome Research Institute, a carcinogen is a substance, organism or agent capable of causing cancer. The International Agency for Research on Cancer (IARC) also classifies alcohol as Group 1 carcinogen, which means, there is enough evidence to conclude that it causes cancers in human. The risk of cancer increases with the amount of alcohol consume, and the risk stats from the first drink. As per a new study, it is also linked to pancreatic cancer. While for the longest, the scientific community had "limited" or "inconclusive" connection on it. However, a large study by the World Health Organization's (WHO) IARC looked at data from around 2 million people across 30 studies in four continents. This was done for over 16 years. What Did The Study Find?The study found a slight rise in pancreatic cancer risk linked to alcohol consumption, regardless of gender or smoking status. The increase was more pronounced in women consuming 15 grams or more of alcohol daily, and in men who drank 30 grams or more per day.The study has been published in PLOS Medicine, and it found a modest yet consistent link between alcohol consumption and pancreatic cancer risk. The study found that for every 10 grams of alcohol that is consumed by a person on a daily basis, which amounts to a small glass of wine, the pancreatic cancer risk increases by 3 percent. What Does "Modest Risk" Mean?Among women who consumed between 15 and 30 grams of alcohol per day, the risk of developing pancreatic cancer increased by 12 percent compared to those with only light intake (0.1–5 grams/day). In men, the danger climbed more steeply—those drinking 30 to 60 grams daily faced a 15 percent higher risk, while men consuming over 60 grams saw their risk surge by a striking 36 percent.Put simply, if your daily wind-down routine involves more than the occasional drink, it may be worth thinking twice about what that glass is really costing your health.How Does Alcohol Pave Way For Pancreatic Cancer?Triggers Inflammation: Long-term alcohol use can irritate and inflame the pancreas, a condition known as pancreatitis. Over time, this chronic inflammation becomes a known risk factor for pancreatic cancer.Damages Genetic Material: When alcohol breaks down in the body, it turns into acetaldehyde—a toxic compound that’s notoriously harsh on DNA. It can lead to mutations and interfere with your body’s natural ability to repair damaged cells.Disrupts Glucose Balance: Alcohol interferes with glucose metabolism and insulin function. Since the pancreas plays a central role in both, this disruption puts it under considerable stress and may increase the likelihood of tumour development over time.Drives Oxidative Stress: Drinking introduces oxidative stress—an unhealthy imbalance between damaging free radicals and protective antioxidants. This imbalance harms cell structures and creates an environment in which cancer can thrive.Lowers Immune Defences: Consistent alcohol consumption weakens the immune system, making it harder for the body to detect and eliminate abnormal or potentially cancerous cells before they multiply.That said, the study isn’t without limitations. It measured alcohol intake only once during the study period and had limited data from Asian populations. It also didn’t explore lifetime drinking patterns or compare the impacts of occasional binge drinking with regular consumption.While pancreatic cancer ranks twelfth in global cancer incidence, it is far deadlier than its ranking suggests—contributing to roughly 5 percent of all cancer-related deaths worldwide.

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10 Children Conceived From Same Sperm Diagnosed With Cancer, Investigation Reveals Donor Has Rare Cancer Genes

Quick Stories

“Stealth Stage” Of Alzheimer's Could Show Signs 20 Years Before The Disease Itself

New Cancer Therapy Increases Survival Rate By 40%: Study

Drinking Even In Moderation Can Increase Your Cancer Risk In This Organ, Finds Study

Health Conditions A-Z

“Stealth Stage” Of Alzheimer's Could Show Signs 20 Years Before The Disease Itself

Is 'Histamine Intolerance' The Hidden Reason Behind Your Bloating And Brain Fog?

New Cancer Therapy Increases Survival Rate By 40%: Study