Have you noticed sudden wrinkles, aches, or just a feeling of growing older overnight? According to new research, there may be a scientific reason for this. Studies suggest that ageing doesn’t happen gradually over time as we often believe. Instead, it occurs in two significant bursts.Two Key Bursts of AgeingA recent study, which tracked people aged 25 to 75, discovered that two major waves of ageing occur at around the ages of 44 and 60. These findings help explain why certain health issues, such as joint pain, cardiovascular problems, and even changes in metabolism, tend to spike at these specific ages.“We don’t just age gradually. There are some big changes happening at certain points,” explained Prof. Michael Snyder, a geneticist at Stanford University and senior author of the study. He pointed out that both the mid-40s and early 60s are critical times of rapid change in the body.How the Study Was ConductedThe research followed 108 participants who provided blood, stool, skin, oral, and nasal samples every few months for periods ranging from one to nearly seven years. Researchers analysed these samples to examine 135,000 different molecules and microbes, including bacteria, viruses, and fungi present in the participants’ bodies.Interestingly, the abundance of most of these molecules and microbes didn’t change slowly and steadily over time. Instead, the researchers found that dramatic shifts happened during two specific age ranges: the mid-40s and early 60s. These shifts were observed in both men and women, suggesting that factors other than menopause could be influencing aging in the mid-40s.Key Findings on Ageing ChangesThe first wave of changes, occurring around age 44, included molecules related to cardiovascular health and the body’s ability to metabolise substances such as caffeine, alcohol, and fats. The second wave of changes, observed around age 60, involved molecules linked to immune regulation, metabolism, and kidney function. Interestingly, molecules associated with skin and muscle aging changed during both these time periods.While earlier research had suggested a third wave of aging might occur around the age of 78, this study couldn’t confirm it because the oldest participants were only 75.What These Findings Mean for Our HealthThis pattern of ageing fits with earlier research that shows the risk of many age-related diseases doesn’t increase gradually over time. Instead, diseases like Alzheimer’s and heart disease often see a sharp increase after the age of 60. The study also suggested that some changes, such as a decrease in alcohol metabolism, could be influenced by lifestyle choices. For example, increased alcohol consumption during mid-life, a particularly stressful period for many, may contribute to these shifts.The study’s findings suggest that targeting lifestyle changes during these periods of rapid aging may help slow down the process. The researchers believe that taking action, such as increasing exercise during times of rapid muscle loss, could help people maintain their health for longer. As Prof. Snyder stated, “We should try to adjust our lifestyles while we’re still healthy.”