A few years ago, we were being warned how air pollution may affect our lungs and make us weak. Now, we are facing this reality and much worse! High levels of air pollution may worsen Alzheimer's disease by speeding up the buildup of harmful proteins in the brain. According to a new study, people with Alzheimer's disease who lived in areas with more air pollution had a greater buildup of these proteins and a faster decline in their thinking and memory skills. The study, published in the JAMA Neurology from the Perelman School of Medicine at the University of Pennsylvania, showed that small toxins from pollution can damage our brain. The researchers explained that not only does this increase the risk of dementia, but it also makes Alzheimer’s worse. Could this mean pollution ages and damages our brain faster than our biological age? The researchers explored these question as well as how the small particles from pollution cause our brain health to deteriorate. How Does Air Pollution Raise Risk Of Dementia? For the first time, researchers studied brain tissue from people who had Alzheimer's. They found that those who lived in areas with higher levels of tiny air particles, even for just one year, had more severe buildup of amyloid plaques and tau tangles. These are two key signs of Alzheimer's in the brain. These individuals also experienced a quicker decline in their mental abilities, including memory loss, poor judgment, and difficulty with daily tasks. "This study shows that air pollution doesn’t just increase the risk of dementia—it actually makes Alzheimer’s disease worse," said Dr. Edward Lee, a co-director of Penn's Institute on Aging. What Are Harmful Pollution Particles Called? Air pollution contains very small particles, often called fine particulate matter or PM2.5. These particles are less than 2.5 micrometers wide—about half the width of a single spider web strand. They come from things like car exhaust, factory smoke, and wildfires. Because they are so small, they can be inhaled and absorbed into the bloodstream, causing health problems. Past studies have already linked PM2.5 to memory loss and cognitive decline. How Small Pollution Particles Affect Brain Researchers looked at over 600 brain samples from a brain bank. By using satellite data and local air monitors, they were able to estimate the level of PM2.5 where each person lived. They found that for every small increase in PM2.5, the risk of more severe amyloid and tau buildup increased by 19 percent. In addition, the study showed that those who lived in highly polluted areas and had more advanced brain damage also had more severe memory loss, speech difficulties, and poor judgment. While this study focused on air pollution based on where people lived, researchers noted they couldn't account for other personal exposures, like secondhand smoke or exposure to chemicals at work. According to Dr. Lee, "even just a year living in an area with high levels of pollution can have a big impact on a person’s risk for developing Alzheimer’s disease. It underscores the value of environmental justice efforts that focus on reducing air pollution to improve public health."
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