There is always a concern whenever people get tattoos done. Of course one of them is whether they would be allowed to donate blood, but the another one is about their own health. Are there foreign particles being inserted in your body? Is it safe? Is it cancerous? Some of these fears might be true. A new study published in BMC Health, titled, Tattoo ink exposure is associated with lymphoma and skin cancers – a Danish study of twins, suggest that tattoos may increase the risk of skin cancer and lymphoma. What Did The Study Find?The study was conducted by the researchers from the University of Southern Denmark, who found that tattoos appear to raise the risk of skin cancer by 33% to 62%. The study also indicated a greater cancer risk for those with larger tattoos. As tattoos larger than the palm of a hand were found to more than double the risk of skin cancer and triple the risk of lymphoma, which is a cancer that affects the lymph nodes. How Does Tattoo Ink Affect The Body?When tattoo ink is injected into the skin, the particles travel to and accumulate in the lymph nodes. This could in return trigger a persistent immune response. Henrik Frederiksen, a clinical professor at the University of Southern Denmark said, "We can see that ink particles accumulate in the lymph nodes, and we suspect that the body perceives them as foreign substances. This may mean that the immune system is constantly trying to respond tot he ink, and we do not yet know whether this persistent strain could weaken the function of the lymph nodes or have other health consequences."How Was The Study Conducted?The researchers analyzed data from an ongoing Danish twin study where they were able to compare nearly 2,400 randomly selected twins born between 1960 and 1966. It also included 316 twin pairs where one twin had been diagnosed with cancer. "The unique aspect of our approach is that we can compare twin pairs where one has cancer, but they otherwise share many genetic and environmental factors." said Jacob von Bornemann Hjelmborg, a professor of biostatistics at the University of Southern Denmark. The researchers then analyzed tattoo patterns and cancer diagnoses and found a high occurrence of skin cancer and lymphoma among tattooed individual. Larger tattoos were also found to be associated with a 2.4 fold increase in skin cancer, while a 2.8 fold increase in lymphoma risk. Have There Been Previous Study On The Same?Previously done studies have suggested that certain pigments in tattoo ink could be more harmful than others. However, the study found no direct link between cancer and specific ink colors. Though, red ink has been known to cause allergic reactions more frequently. “We know from other studies that ink can contain potentially harmful substances, and for example, red ink more often causes allergic reactions. This is an area we would like to explore further,” said lead researcher Signe Bedsted Clemmensen, an assistant professor of biostatistics at the University of Southern Denmark.Researchers now also plan to investigate how ink particles affect the lymph nodes and whether certain types of lymphoma have stronger association with tattoos. Commenting on this, the lead researcher said, "“We want to gain a better understanding of the biological mechanisms — what happens in the lymph nodes when they are exposed to ink particles over decades? This can help us assess whether there is a real health risk and what we might do to reduce it."