As per the World Health Organization (WHO), 57 million people had dementia worldwide in 2021. the Alzheimer's Disease International (ADI) predicted that this number will almost double every 20 years and reach 78 million in 2030. However, there is hope. An Indian origin researcher in the US developed a probiotic cocktail that will help prevent dementia.What Is Dementia?As per Alzheimer's Association, dementia is a general term for loss of memory, language, problem-solving and other thinking abilities that are severe enough to interfere with daily life. Alzheimer's is the most common cause of dementia. It is an umbrella term for loss of memory and other thinking abilities that are severe enough to interfere with daily life. There are various types of dementia, including Alzheimer's, Vascular, Lewy body, Frontotemporal, other includes Huntington's and mixed dementia. What Is Anti-Dementia Probiotic Cocktail?The cocktail is developed by Hariom Yadav from the University of South Florida. It is one of a kind of blend of probiotics that can positively impact the microbiome. Hariom Yadav, director of the USF Health Center for Microbiome Research and associate professor of Neurosurgery and Brain Repair at the USF Health Morsani College of Medicine, is leading the charge. As senior author of two recent studies, his work centers on how gut health affects the brain and cognitive function.The microbiome is the unseen community of microorganisms that live by the trillions in a person's gut. This probiotic cocktail works by positively influencing the microbiome—the vast, invisible community of trillions of microorganisms living in our gut.When the Gut Goes WrongIn a healthy person, these microorganisms coexist in balance. However, when harmful bacteria and viruses disrupt this harmony, it can trigger systemic issues throughout the body. Research now links such disruptions to long-term brain conditions, including dementia and Alzheimer’s disease. This is particularly alarming as dementia cases are expected to double, reaching nearly a million new diagnoses annually by 2060.Probiotic Cocktail Shows PromiseIn a study published in Scientific Reports in January, Yadav’s team tested the cocktail, which combines multiple strains of beneficial gut bacteria. Unlike current Alzheimer’s treatments that focus solely on brain biology, this cocktail offers a new direction—targeting the gut to protect the brain.Testing the Cocktail on MiceTo evaluate its effects, mice were given the probiotic blend in their drinking water for 16 weeks. They then completed a "water maze" test, which challenged them to find a hidden underwater platform using visual cues. Mice that consumed the cocktail consistently outperformed those that didn’t.Positive Results in Brain HealthThe researchers observed that the probiotic mixture reduced the accumulation of harmful brain proteins linked to plaque formation. It also appeared to decrease brain inflammation and maintain the integrity of the blood-brain barrier, preventing dangerous microorganisms from leaking into the brain.A Synergistic Approach to Gut Health“We actually developed this cocktail a few years back,” said Yadav. “Normally, people look at single-strain probiotics. But we discovered that when used together as a consortia, they have more power to shift the microbiome from harmful to beneficial.”