Among the many rare conditions which are life-threatening, Dr Sermed Mezher, a doctor based in London, a medicine physician and a content creator shared a video explaining 'one of the worst pregnancy complications'. He says, "There's been a very public case of a 33-year-old woman, who sadly passed away from an exceptionally rare complication of pregnancy recently." View this post on Instagram A post shared by Sermed Mezher (@drsermedmezher)]]>What Are The Facts?It is called an amniotic fluid embolism, or AFE, which is a rare, but extremely dangerous childbirth complication, he explains. It happens when amniotic fluid, fetal cells, or other debris enter the mother's bloodstream, triggering a severe and sudden immune response. This can lead to rapid cardiovascular collapse, respiratory failure, and life-threatening bleeding due to disseminated intravascular coagulation (DIC), he explains. He says that it is most difficult to manage this complications during delivery, "as it is when part of the actual amniotic fluid that surrounds the baby or some fetal cells actually get into the maternal bloodstream and spreads to the rest of the body." It causes the whole systems inflammatory allergic reaction. Why Is It So Difficult To Manage?He shares that it is because, at this stage multiple systems can start failing at the same time. It leads to cardio respiratory collapse, oxygen levels start plummeting, blood pressure starts falling, and also causes excessive bleeding of something called DIC. DIC is where clotting factors are all being used up in the blood, and the patient can have seizures at the same time. He, however does mention that it is an incredibly rare complication, which affects only 1 in 40 to 50,000 pregnancies, between 11 and 43% of mothers not making it through the complication.What Is AFE?As per the National Library of Medicine, it is a rare but serious condition with high mortality and morbidity rates and is the second leading cause of peripartum maternal death. It occurs when amniotic fluid enters the maternal bloodstream. Cardiovascular collapse is often the first sign of amniotic fluid embolism (AFE). It is typically followed by activation of the clotting and fibrinolytic systems, which may lead to disseminated intravascular coagulation. Since no specific test exists, AFE is diagnosed based on clinical assessment.What May Increase Your Chance of AFE?Advanced maternal age (being older than 35 during pregnancy)Expecting multiples (twins, triplets or more)Fetal distress (changes to the fetal heart rate)Issues with the placenta like placental abruptionPreeclampsia or eclampsiaPolyhydramnios (too much amniotic fluid)Cervical tearsLabor induction medications or proceduresHaving a C-section deliveryOperative assisted deliveries (forceps delivery or vacuum extraction)Are There Any Symptoms?Signs and symptoms of AFE develop suddenly and quickly, and often they are similar to that of other ordinary complication of pregnancy, which makes it difficult to detect the condition. However, these could be the following symptoms:Shortness of breath or difficulty breathingSudden drop in blood pressurePulmonary edema (fluid in your lungs)Abnormal heart rateBleeding from your uterus, C-section incision or IV (intravenous) sitesFetal distressAgitation, confusion or sudden anxietyChills