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Aarushi Bhadury

10 Children Conceived From Same Sperm Diagnosed With Cancer, Investigation Reveals Donor Has Rare Cancer Genes

10 Children Conceived From Same Sperm Diagnosed With Cancer

Ever considered <span>sperm donation</span> or to conceive through this process? If yes, then this news could concern you.While it is true that sperm health and the person who is donating matters, however, sometimes it can go unchecked. The consequence could be life threatening. In another news, a man whose sperm was used to conceive at least 67 children is found to be carrying a rare <span><a href="https://www.healthandme.com/health/cancer">cancer</a></span> causing mutation. Of the children, 10 of them were diagnosed with cancer. This has raised concerns about the lack of internationally agreed limits on the use of donor sperm.

The Guardian reports that two of the children's families reach out to their respective fertility clinics after their kids were diagnosed with cancer. This is when the sperm was linked to a rare genetic mutation. This case was also presented by Dr Edwige Kasper, a French biologist at the European Society of Human Genetics conference in Milan.

The European Sperm Bank confirmed that the rare variant which Kasper's lab concluded was likely to be Li-Fraumeni syndrome. This was also found in the supplied sperm. The syndrome is an inherited predisposition to cancer, and it has been found in more than two children.

<h2>What Is Li-Fraumeni Syndrome (LFS)?</h2>

It is a cancer predisposition syndrome associated with high risks for a broad spectrum of cancers including early-onset cancers. Five cancers types account for the majority of the LFS tumors: adrenocortical <span>carcinomas</span>, breast cancer, central nervous system tumors, ostesarcomas, and soft-tissue sarcomas. Other cancers associated with LFS are leukemia, colorectal cancer, stomach cancer, lung cancer, melanoma, pediatric head and neck cancers, pancreatic cancer, and prostate cancer.

This was named after two American physicians, Frederick Pel Li and Joseph F Fraumeni Jr., who first recognized this syndrome after reviewing the medical records and death certificates of childhood rhabdomyosarcoma patients.

This mutation is caused by germline mutations in the TP53 tumor suppressor gene, also mentioned in Germline TP53 mutations and Li-Fraumeni syndrome study. This encodes a transcription factor (p53) that normally regulates cell cycle and prevents genomic mutations. The variants can be inherited, or can arise from mutations early in embryogenesis, or in one of the parent's germ cells.

A spokesperson of the company, Juli Paulli Budtz, told The Guardian that the company is “deeply affected by this case.”

Budtz also said that “it is simply not possible to detect disease-causing mutations in a person’s gene pool if you don’t know what you’re looking for,” indicating that prior testing may or may not detect this rare genetic mutation in the sperm donor.

Another detail revealed in The Guardian noted that the time of donation was 2008, when cancer was not linked to the genetic mutation. Thus despite any test, it wouldn’t have been possible to know whether the sperm could have been a cancer career. The Guardian also reported that the outlet also said that the donor is in good health.

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Ever considered sperm donation or to conceive through this process? If yes, then this news could concern you.While it is true that sperm health and the person who is donating matters, however, sometimes it can go unchecked. The consequence could be life threatening. In another news, a man whose sperm was used to conceive at least 67 children is found to be carrying a rare cancer causing mutation. Of the children, 10 of them were diagnosed with cancer. This has raised concerns about the lack of internationally agreed limits on the use of donor sperm.How Was This Discovered?The Guardian reports that two of the children's families reach out to their respective fertility clinics after their kids were diagnosed with cancer. This is when the sperm was linked to a rare genetic mutation. This case was also presented by Dr Edwige Kasper, a French biologist at the European Society of Human Genetics conference in Milan.The European Sperm Bank confirmed that the rare variant which Kasper's lab concluded was likely to be Li-Fraumeni syndrome. This was also found in the supplied sperm. The syndrome is an inherited predisposition to cancer, and it has been found in more than two children.What Is Li-Fraumeni Syndrome (LFS)?It is a cancer predisposition syndrome associated with high risks for a broad spectrum of cancers including early-onset cancers. Five cancers types account for the majority of the LFS tumors: adrenocortical carcinomas, breast cancer, central nervous system tumors, ostesarcomas, and soft-tissue sarcomas. Other cancers associated with LFS are leukemia, colorectal cancer, stomach cancer, lung cancer, melanoma, pediatric head and neck cancers, pancreatic cancer, and prostate cancer.This was named after two American physicians, Frederick Pel Li and Joseph F Fraumeni Jr., who first recognized this syndrome after reviewing the medical records and death certificates of childhood rhabdomyosarcoma patients.This mutation is caused by germline mutations in the TP53 tumor suppressor gene, also mentioned in Germline TP53 mutations and Li-Fraumeni syndrome study. This encodes a transcription factor (p53) that normally regulates cell cycle and prevents genomic mutations. The variants can be inherited, or can arise from mutations early in embryogenesis, or in one of the parent's germ cells.The Impact Of Rare Cancer GeneA spokesperson of the company, Juli Paulli Budtz, told The Guardian that the company is “deeply affected by this case.”Budtz also said that “it is simply not possible to detect disease-causing mutations in a person’s gene pool if you don’t know what you’re looking for,” indicating that prior testing may or may not detect this rare genetic mutation in the sperm donor.Another detail revealed in The Guardian noted that the time of donation was 2008, when cancer was not linked to the genetic mutation. Thus despite any test, it wouldn’t have been possible to know whether the sperm could have been a cancer career. The Guardian also reported that the outlet also said that the donor is in good health.

10 children conceived from same sperm diagnosed with cancer, investigation reveals donor has rare cancer genes

(Credit-Canva)

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While there have been many debates about sparkling water and whether it is safe for consumption, studies have shown that it has many benefits for our health but what is sparkling water aka carbonated water? Carbonated water is water which has been infused with carbon dioxide gas, which creates the bubbly drink. They are served as club soda, sparkling water, soda water etc. What makes it different from normal water is that the carbon dioxide in the sparkling water produces carbonic acid, which is a weak acid that causes a burning prickly sensation. 

Research has shown that it can actually help improve our digestion, and they make a great addition to other drinks as well. Many of us love the refreshing fizz of sparkling water, but a doctor warns it might not be as healthy as still water for everyone. Dr. Julio Maset, known as @cinfasalud on Instagram, explains that while both sparkling and still water hydrate and have no calories, they aren't always interchangeable. 

Sparkling water can help with digestion and ease that heavy feeling after a big meal. However, it's crucial to understand when still water is the better choice for your body.

Experts caution that some people should avoid sparkling water. If you suffer from gastroesophageal reflux (acid reflux) or <span>irritable bowel syndrome</span> (IBS), sparkling water might cause discomfort. Experts also point out that sparkling water is more acidic in the mouth, which could potentially erode dental enamel over time, though not as much as sugary drinks. To minimize this risk, it's best to drink it with meals and in moderation. The main takeaway is not to completely replace still water; it remains the top choice for daily hydration. However, sparkling water can be a healthy swap if it means cutting out sugary soft drinks. 

<h2>Link Between Carbonation and Irritable Bowel Syndrome (IBS)</h2>

According to Livestrong, certain foods and drinks can trigger symptoms for people with Irritable Bowel Syndrome (IBS), even though the exact connection isn't fully understood. Carbonated drinks, including sparkling water, are on this list, alongside dairy, beans, wheat, cabbage, and citrus fruits. 

While drinking carbonated beverages won't cause IBS or diarrhea, they can definitely trigger bloating and gas because you're literally consuming gas bubbles. If these bubbly drinks also contain sugar or artificial sweeteners, they're even more likely to cause diarrhea for those sensitive to them. 

<h2>What Are Some Other Foods To Avoid In IBS </h2>

Milk and dairy containing lactose can cause gas and bloating for many. Most adults don't make enough lactase to digest it. However, yogurt is often an exception, as its live cultures break down lactose, reducing gassy symptoms. 

High-fructose corn syrup in processed foods can worsen IBS symptoms. Even healthy foods like apples, pears, and dried fruits are naturally high in fructose. For IBS, berries, citrus, and bananas might be better choices. 

The bubbles in carbonated drinks like soda and seltzer can cause gas. Stick to water and lactose-free milk. Caffeine in coffee, tea, and cola can also increase diarrhea, a common IBS symptom. 

Many sugar-free gums use artificial sweeteners like sorbitol and xylitol, which can cause diarrhea. Chewing gum also makes you swallow more air, leading to extra gassiness and discomfort. 

diet & nutrition

sparkling water benefits

irritable bowel syndrome

ibs syndrome

stomach ache

what is carbonated water

While there have been many debates about sparkling water and whether it is safe for consumption, studies have shown that it has many benefits for our health but what is sparkling water aka carbonated water? Carbonated water is water which has been infused with carbon dioxide gas, which creates the bubbly drink. They are served as club soda, sparkling water, soda water etc. What makes it different from normal water is that the carbon dioxide in the sparkling water produces carbonic acid, which is a weak acid that causes a burning prickly sensation. Research has shown that it can actually help improve our digestion, and they make a great addition to other drinks as well. Many of us love the refreshing fizz of sparkling water, but a doctor warns it might not be as healthy as still water for everyone. Dr. Julio Maset, known as @cinfasalud on Instagram, explains that while both sparkling and still water hydrate and have no calories, they aren't always interchangeable. Sparkling water can help with digestion and ease that heavy feeling after a big meal. However, it's crucial to understand when still water is the better choice for your body.Experts caution that some people should avoid sparkling water. If you suffer from gastroesophageal reflux (acid reflux) or irritable bowel syndrome (IBS), sparkling water might cause discomfort. Experts also point out that sparkling water is more acidic in the mouth, which could potentially erode dental enamel over time, though not as much as sugary drinks. To minimize this risk, it's best to drink it with meals and in moderation. The main takeaway is not to completely replace still water; it remains the top choice for daily hydration. However, sparkling water can be a healthy swap if it means cutting out sugary soft drinks. Link Between Carbonation and Irritable Bowel Syndrome (IBS)According to Livestrong, certain foods and drinks can trigger symptoms for people with Irritable Bowel Syndrome (IBS), even though the exact connection isn't fully understood. Carbonated drinks, including sparkling water, are on this list, alongside dairy, beans, wheat, cabbage, and citrus fruits. While drinking carbonated beverages won't cause IBS or diarrhea, they can definitely trigger bloating and gas because you're literally consuming gas bubbles. If these bubbly drinks also contain sugar or artificial sweeteners, they're even more likely to cause diarrhea for those sensitive to them. What Are Some Other Foods To Avoid In IBS Dairy Products Milk and dairy containing lactose can cause gas and bloating for many. Most adults don't make enough lactase to digest it. However, yogurt is often an exception, as its live cultures break down lactose, reducing gassy symptoms. Foods High in Fructose High-fructose corn syrup in processed foods can worsen IBS symptoms. Even healthy foods like apples, pears, and dried fruits are naturally high in fructose. For IBS, berries, citrus, and bananas might be better choices. Fizzy Drinks and Caffeine The bubbles in carbonated drinks like soda and seltzer can cause gas. Stick to water and lactose-free milk. Caffeine in coffee, tea, and cola can also increase diarrhea, a common IBS symptom. Sugar-Free Gum Many sugar-free gums use artificial sweeteners like sorbitol and xylitol, which can cause diarrhea. Chewing gum also makes you swallow more air, leading to extra gassiness and discomfort. 

drinking sparkling water if you have this condition may be causing you stomach symptoms

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India is no stranger to the <span>monsoon</span>, but in recent times, <span>untimely rainfall</span>, during the summers has become a recurring and worrying pattern. Sudden downpours and extended wet spells, often hitting before or after the traditional monsoon season, have created favorable conditions for a surge in seasonal <span>diseases</span>. Public health experts are increasingly concerned that this erratic weather is putting millions of Indians at risk, particularly in urban areas where poor drainage and sanitation aggravate the problem.

<h4>Why Untimely Rainfall Is a Health Hazard</h4>

Unseasonal rains lead to prolonged humidity and stagnant water, two ideal conditions for the breeding of disease-carrying mosquitoes and the spread of bacteria and viruses. Overflowing drains, waterlogged streets, and contaminated water supplies become hotspots for infection. With climate change making such weather more frequent, India’s already burdened healthcare system faces further pressure during the monsoon and beyond.

<h4>Here Is a List of 10 Most Common <span rel="noindex">Monsoon Diseases</span>:</h4>

Spread by the Aedes mosquito (often called the tiger mosquito), dengue is the most widespread monsoon disease. To prevent bites, apply mosquito repellent gel or lotion regularly.

<ul><li>High fever</li><li>Swollen lymph nodes</li><li>Skin rashes</li><li>Headache</li><li>Low platelet count</li><li>Hypersensitivity</li></ul>

Caused by mosquitoes that breed in stagnant water, often in overhead tanks, coolers, or unused containers.

<ul><li>Intense joint pain</li><li>High fever</li><li>Fatigue</li><li>Chills</li></ul>

Another mosquito-borne illness that spikes during monsoon due to waterlogging.

<ul><li>Recurring high fever</li><li>Chills and sweating</li><li>Body ache</li><li>Severe anemia</li></ul>

Caused by consuming contaminated food or water, particularly where sanitation is poor.

<ul><li>Dehydration</li><li>Muscle cramps</li><li>Low blood pressure</li><li>Rapid heartbeat</li><li>Loss of skin elasticity</li></ul>

A highly contagious bacterial disease, often resulting from unhygienic food and water.

<ul><li>Prolonged high fever</li><li>Weakness</li><li>Abdominal pain</li><li>Vomiting</li></ul>

Common during monsoon, this illness spreads easily due to temperature fluctuations and humidity.

<ul><li>Fever</li><li>Fatigue</li><li>Chills</li><li>Muscle and joint pain</li><li>Inflammation of the throat</li></ul>

Typically caused by unhygienic food or water, diarrhea can become dangerous if left untreated.

<ul><li>Watery stools</li><li>Abdominal cramps</li><li>Fever</li><li>Nausea</li></ul>

Fluctuating weather often leads to cold and flu symptoms, which can spread quickly.

<ul><li>Fever</li><li>Muscle ache</li><li>Headache</li><li>Nasal congestion</li><li>Persistent cough</li></ul>

Transmitted from animals to humans, this bacterial infection becomes common in waterlogged areas.

<ul><li>High fever</li><li>Headache</li><li>Red eyes</li><li>Abdominal pain</li><li>Rashes</li></ul>

Caused by the consumption of unhygienic food, leading to infections like gastroenteritis.

<ul><li>Nausea and vomiting</li><li>Abdominal cramps</li><li>Diarrhea</li><li>Low-grade fever</li></ul>

As India grapples with climate change-induced weather patterns, it is essential to stay prepared. Avoid street food, drink only boiled or filtered water, and use mosquito repellents. Basic hygiene practices like washing hands regularly and ensuring proper sanitation can go a long way in protecting yourself and your family during this unpredictable season.

seasonal health

health and wellness

monsoon

untimely monsoon

untimely rainfall

infectious diseases

diseases

monsoon diseases

India is no stranger to the monsoon, but in recent times, untimely rainfall, during the summers has become a recurring and worrying pattern. Sudden downpours and extended wet spells, often hitting before or after the traditional monsoon season, have created favorable conditions for a surge in seasonal diseases. Public health experts are increasingly concerned that this erratic weather is putting millions of Indians at risk, particularly in urban areas where poor drainage and sanitation aggravate the problem.Why Untimely Rainfall Is a Health HazardUnseasonal rains lead to prolonged humidity and stagnant water, two ideal conditions for the breeding of disease-carrying mosquitoes and the spread of bacteria and viruses. Overflowing drains, waterlogged streets, and contaminated water supplies become hotspots for infection. With climate change making such weather more frequent, India’s already burdened healthcare system faces further pressure during the monsoon and beyond.Here Is a List of 10 Most Common Monsoon Diseases:DengueSpread by the Aedes mosquito (often called the tiger mosquito), dengue is the most widespread monsoon disease. To prevent bites, apply mosquito repellent gel or lotion regularly.Symptoms:High feverSwollen lymph nodesSkin rashesHeadacheLow platelet countHypersensitivityChikungunyaCaused by mosquitoes that breed in stagnant water, often in overhead tanks, coolers, or unused containers.Symptoms:Intense joint painHigh feverFatigueChillsMalariaAnother mosquito-borne illness that spikes during monsoon due to waterlogging.Symptoms:Recurring high feverChills and sweatingBody acheSevere anemiaCholeraCaused by consuming contaminated food or water, particularly where sanitation is poor.Symptoms:DehydrationMuscle crampsLow blood pressureRapid heartbeatLoss of skin elasticityTyphoidA highly contagious bacterial disease, often resulting from unhygienic food and water.Symptoms:Prolonged high feverWeaknessAbdominal painVomitingViral FeverCommon during monsoon, this illness spreads easily due to temperature fluctuations and humidity.Symptoms:FeverFatigueChillsMuscle and joint painInflammation of the throatDiarrheaTypically caused by unhygienic food or water, diarrhea can become dangerous if left untreated.Symptoms:Watery stoolsAbdominal crampsFeverNauseaInfluenzaFluctuating weather often leads to cold and flu symptoms, which can spread quickly.Symptoms:FeverMuscle acheHeadacheNasal congestionPersistent coughLeptospirosisTransmitted from animals to humans, this bacterial infection becomes common in waterlogged areas.Symptoms:High feverHeadacheRed eyesAbdominal painRashesStomach InfectionsCaused by the consumption of unhygienic food, leading to infections like gastroenteritis.Symptoms:Nausea and vomitingAbdominal crampsDiarrheaLow-grade feverStaying Safe During the MonsoonAs India grapples with climate change-induced weather patterns, it is essential to stay prepared. Avoid street food, drink only boiled or filtered water, and use mosquito repellents. Basic hygiene practices like washing hands regularly and ensuring proper sanitation can go a long way in protecting yourself and your family during this unpredictable season.

You Can Reduce Dementia Risk By Walking Only These Number Of Steps

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Many of us aim for 10,000 steps a day, but new research suggests you might not need to walk quite that much to help lower your risk of <span>dementia</span>. A study using wearable trackers found that even fewer steps can make a real difference. Experts have shared that taking 9,800 steps a day can reduce your dementia risk. What's even better is that you get half of that benefit by just taking about 3,800 steps, or around 4,000. This is great news, as it's a more achievable goal for many people looking to boost their brain health.

It's not just about how many steps you take; how you walk also matters. The study on <span>walking and dementia</span> risk showed that taking purposeful steps and walking with more intensity, like a brisk walking pace, were linked to a lower risk of dementia. So, a faster walk is more helpful than a slower walk. Experts also highlighted the benefits of walking in groups, especially for older adults. Walking with others can build social connections, improve your mood, and fight off feelings of loneliness, all of which are important for your overall well-being. 

<h2>How Exercise Impact Dementia Risk?</h2>

Not being active enough is a big risk factor for dementia, studies have consistently shown that regular exercise for middle-aged and older adults can improve thinking and memory and lower the chances of getting dementia. The charity suggests getting about 20 to 30 minutes of aerobic exercise, which is any activity that gets your heart rate up. This can include everyday things like brisk walking, cleaning, or gardening, making it easy to fit into your daily life. 

<h2>Can More Physical Activity Prevent Dementia?</h2>

The NHS also strongly supports the idea that being physically active helps prevent dementia. They explain that not exercising enough can increase your risk of heart disease, becoming overweight, and developing type 2 diabetes – all factors that can raise your dementia risk. Older adults who don't exercise are also more likely to have problems with their memory or thinking. 

The NHS suggests at least 150 minutes of moderate-intensity physical activity each week. This could be brisk walking, cycling, or dancing. They also recommend strengthening exercises twice a week, like gardening or yoga, and encourage you to move regularly throughout the day, even by taking the stairs or standing during phone calls. 

Dementia

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Many of us aim for 10,000 steps a day, but new research suggests you might not need to walk quite that much to help lower your risk of dementia. A study using wearable trackers found that even fewer steps can make a real difference. Experts have shared that taking 9,800 steps a day can reduce your dementia risk. What's even better is that you get half of that benefit by just taking about 3,800 steps, or around 4,000. This is great news, as it's a more achievable goal for many people looking to boost their brain health.It's not just about how many steps you take; how you walk also matters. The study on walking and dementia risk showed that taking purposeful steps and walking with more intensity, like a brisk walking pace, were linked to a lower risk of dementia. So, a faster walk is more helpful than a slower walk. Experts also highlighted the benefits of walking in groups, especially for older adults. Walking with others can build social connections, improve your mood, and fight off feelings of loneliness, all of which are important for your overall well-being. How Exercise Impact Dementia Risk?Not being active enough is a big risk factor for dementia, studies have consistently shown that regular exercise for middle-aged and older adults can improve thinking and memory and lower the chances of getting dementia. The charity suggests getting about 20 to 30 minutes of aerobic exercise, which is any activity that gets your heart rate up. This can include everyday things like brisk walking, cleaning, or gardening, making it easy to fit into your daily life. Can More Physical Activity Prevent Dementia?The NHS also strongly supports the idea that being physically active helps prevent dementia. They explain that not exercising enough can increase your risk of heart disease, becoming overweight, and developing type 2 diabetes – all factors that can raise your dementia risk. Older adults who don't exercise are also more likely to have problems with their memory or thinking. The NHS suggests at least 150 minutes of moderate-intensity physical activity each week. This could be brisk walking, cycling, or dancing. They also recommend strengthening exercises twice a week, like gardening or yoga, and encourage you to move regularly throughout the day, even by taking the stairs or standing during phone calls. 

reduce dementia risk by walking these number of steps

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10 Children Conceived From Same Sperm Diagnosed With Cancer, Investigation Reveals Donor Has Rare Cancer Genes

Quick Stories

Could Sparkling Water Be Causing Stomach Pain And Digestive Distress?

Untimely Rainfall Leaves The Country Prone To These Infectious Diseases

You Can Reduce Dementia Risk By Walking Only These Number Of Steps

Health Conditions A-Z

Could Sparkling Water Be Causing Stomach Pain And Digestive Distress?

Untimely Rainfall Leaves The Country Prone To These Infectious Diseases

This 'Sweet and Sour' Fruit Juice Can Help Ease Sore Throat While Reducing Your Cancer Risk