A staple plant with glycyrrhiza glabra origins for its medical properties and sweet flavouring since antiquity, a native plant in Asia, Southern Europe, and the Middle East, is licorice root, which is prized for being brewed in the ancient kingdom of Egypt, where the Egyptians prepared its sweet drink for kings and queens. Currently, licorice root is applied as a health medicine and a constituent of food.With nearly 300 bioactive compounds, the main bioactive compound glycyrrhizin, which forms the basis of antioxidant, anti-inflammatory, and antimicrobial properties. Nevertheless, the multiple health benefits associated with its use mean it has to be used carefully due to side effects. Possible Licorice Root Health Benefits1. Supports Skin DiseasesLicorice root has been used to treat skin conditions such as acne and eczema. Studies have demonstrated that creams with licorice root extracts are as potent as hydrocortisone-based creams for eczema, reducing redness, swelling, and irritation. Its anti-inflammatory properties make it a good natural remedy for soothing sensitive or irritated skin. 2. Relieving Acid Reflux and IndigestionIt is widely recommended for the management of GERD symptoms such as acid reflux, heartburn, and indigestion. A study published in 2017 with 58 participants proved that taking licorice root on a daily basis reduced the symptoms of GERD within two years of consumption. This surpasses traditional antacids and makes it a natural alternative for digestive comfort. 3. It aids in the treatment of peptic ulcersPeptic ulcers caused by H. pylori bacteria may be painful. It was suggested in studies that glycyrrhizin found in licorice root promotes healing and protects against inflammation, maintains gut health. It improves the efficacy of treatment given the standard management can now work in harmony with its properties toward more holistic treatment of peptic ulcers. 4. Anti-cancer PropertiesPreliminary research shows that the licorice root could have anticancer activity. Research in the laboratory setting demonstrated its compounds slow or stop the development of cancer cells in skin, colorectal, and breast cancers. In addition to this, the root can help manage oral mucositis, which is an extremely painful side effect of chemotherapy. Its use in treating cancer, however, has yet to be proven through human trials. 5. Helping Relieve Respiratory DisordersLicorice root's anti-inflammatory properties may benefit those with respiratory ailments such as asthma or chronic obstructive pulmonary disease (COPD). Studies suggest that glycyrrhizin, a key compound, enhances bronchodilator effectiveness and protects lung tissue from oxidative damage. Furthermore, licorice root tea has shown promise in alleviating symptoms of strep throat and other upper respiratory infections. 6. Promoting Oral HealthIt is known that licorice root may prevent cavities, tooth decay, and other oral conditions like thrush and periodontitis. Antimicrobial properties will combat bacteria causing oral health issues; however, more studies need to be conducted on dosage and usage. Precautions to Take and Possible Side EffectsLicorice root is generally safe to consume but can cause severe side effects when taken in excess since glycyrrhizin accumulates in the body, leading to electrolyte imbalance, increased cortisol, and blood pressure. In the long term, it causes such effects as: Hypertension Low levels of potassium Kidney damage Heart condition, including arrhythmia and congestive heart failureBecause of these risks, heart disease, hypertension, or kidney disease patients should avoid using licorice root. Also, pregnant and nursing mothers should not use it. Drug Interactions Licorice root may interact with a number of medications such as: Blood pressure drugs Blood thinners Diuretics Cholesterol-lowering drugs NSAIDs Estrogen-based contraceptivesIf you are on any of these medications, consult a healthcare provider before using licorice root supplements.Recommended Dosage and UsageThere is no standard dosage for licorice root. However, research has indicated that it is safe to take daily dosages ranging from 1–5 grams. Always follow the manufacturer instructions or seek advice from a health care provider to get recommendations tailored to your specific needs.How to Store Licorice RootTo extend the shelf life, store licorice root supplements in a cool, dry place, not exposed to direct sunlight. Refrigeration is usually not required, but always follow the storage instructions on the product label. Keep the supplements out of reach of children and pets, and discard them when they expire.Licorice root is a product that has a variety of potential health benefits, including aiding digestion and soothing skin conditions, supporting respiratory health, and even possibly fighting cancer. However, it does have risks. Severe side effects can be caused by excessive or long-term use, especially in vulnerable populations. Always consult a healthcare provider and follow recommended dosages for safe and effective use.